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Citation: XU Yulin, GONG Wenpeng, YANG Shuijin. Synthesis of 3,4-Dihydropyrimidine-2(1H)-one Derivatives Using Phosphotungstic Acid Supported on Silica as Catalyst[J]. Chinese Journal of Applied Chemistry, ;2014, 31(10): 1203-1209. doi: 10.3724/SP.J.1095.2014.40046 shu

Synthesis of 3,4-Dihydropyrimidine-2(1H)-one Derivatives Using Phosphotungstic Acid Supported on Silica as Catalyst

1.
College of Chemistry and Chemical Engineering, Hubei Collaborative Innovation Center for Rare Metal Chemistry, Hubei Normal University, Huangshi 435002, China

Corresponding author: YANG Shuijin,
Received Date: 28 February 2014
Available Online: 25 April 2014
Fund Project: 国家自然科学基金(21273065) (21273065)湖北师范学院硕士研究生创新科研基金(1051320130216)项目 (1051320130216)

3,4-Dihydropy-rimidine-2(1H)-one was synthesized from substituted benzaldehyde, ethylacetoacetate and urea using phosphotungstic acid(H₃PW₁₂O₄₀) supported on SiO₂ as a novel eco-friendly catalyst prepared by a sol-gel technique. The influences of the molar ratio of reactants, reaction temperature, catalyst loading and reaction time were discussed. H₃PW₁₂O₄₀/SiO₂ is a good catalyst for the synthesis of 3,4-dihydropyrimidine-2(1H)-one with the yield of 73.1%~88.4% under optimized conditions. The catalyst was characterized by IR, XRD and SEM, and the products were characterized by ¹H NMR, IR and MS.
- sol-gel technique,
- phosphotungstic acid/silicca,
- catalysis,
- synthesis,
- dihydropy-rimidine-2(1H)-one
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