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Citation: WANG Zunzhi, ZHANG Jianfu, CHEN Dongdong. Layer-by-Layer Assembled Antibacterial Microgel Films on Urethral Catheter[J]. Chinese Journal of Applied Chemistry, ;2014, 31(10): 1149-1155. doi: 10.3724/SP.J.1095.2014.30617 shu

Layer-by-Layer Assembled Antibacterial Microgel Films on Urethral Catheter

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a Department of Teaching Basic Courses, Armed Police Academy, Langfang 065000, China;
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b State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, China

Corresponding author: WANG Zunzhi,
Received Date: 6 December 2013
Available Online: 18 December 2013

The prevention of hospital-acquired infection attributable to indwelling urethral catheter use has recently received increased attention. For controlled release of antibacterial drugs, antibacterial films with a thickness less than 500 nm on urethral catheter were directly constructed by layer-by-layer deposition of poly(allylamine hydrochloride) and dextran(PAH-D) microgels with hyaluronic acid(HA). PAH-D/HA multilayer films can load negatively charged antibacterial drugs such as ceflriaxone sodium(CTX) in 2 min based on electrostatic interaction between PAH-D microgels and CTX molecules and then release them in 3 h in physiological saline. Direct deposition of microgel films and incorporation of CTX endow the multilayer micro films with an effective antibacterial performance.
- layer-by-layer assembly,
- antibacterial,
- microgel,
- urethral catheter
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