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Citation: MA Congming, LIU Zuliang, YAO Qizheng. Synthesis and Characterization of 5-Substituted Furoxano[3,4-b]pyridine Derivatives[J]. Chinese Journal of Applied Chemistry, ;2014, 31(8): 911-915. doi: 10.3724/SP.J.1095.2014.30569 shu

Synthesis and Characterization of 5-Substituted Furoxano[3,4-b]pyridine Derivatives

1.
a School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094, China;
2.
b School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China

Corresponding author: YAO Qizheng,
Received Date: 13 November 2013
Available Online: 15 January 2014
Fund Project: 国家自然科学基金资助项目(21102125) (21102125)

An intermediate[1,2,5] oxadiazolo[3,4-e] tetrazolo[1,5-a] pyridine-3-oxide(4b) was synthesized using 2,6-dichloropyridine as a primary material,followed by nitration,azide,and cyclization. Compound 4b reacted with concentrated sulfuric acid and potassium nitrate,sodium methoxide,aqueous methylamine to afford 5-substituted furoxano[3,4-b] pyridine derivatives 5~7,respectively. The furoxano group of compound 4b was stable in the presence of strong acid,strong base and weak base,but the tetrazolo group formed by azido group at the ortho-position of the pyridine ring was labile.
- organic chemistry,
- synthesis,
- dichloropyridine,
- furoxano[3,4-b]pyridine derivatives
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