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Citation: LIU Jianchao, LIANG Ying, HE Hongwu. Synthesis and Biological Activity of 6-Alkylamino(oxy)-3-Methylthio-1H-Pyrazolo[3,4-d]pyrimidin-4(5H)-One Derivatives[J]. Chinese Journal of Applied Chemistry, ;2014, 31(8): 922-927. doi: 10.3724/SP.J.1095.2014.30474 shu

Synthesis and Biological Activity of 6-Alkylamino(oxy)-3-Methylthio-1H-Pyrazolo[3,4-d]pyrimidin-4(5H)-One Derivatives

1.
a College of Chemistry, Central China Normal University, Wuhan 430079, China;
2.
b Hubei Biopesticide Engineering Research Center, Hubei Academy of Agricultural Science, Wuhan 430064, China

Corresponding author: HE Hongwu,
Received Date: 23 September 2013
Available Online: 17 December 2013
Fund Project: 国家重点基础研究发展规划项目(973计划)(2010CB126100) (973计划)(2010CB126100)国家自然科学基金资助项目(21172090,31000867) (21172090,31000867)教育部创新团队资助项目(IRT0953) (IRT0953)国家科技支撑计划(2011BAE06B04) (2011BAE06B04)

The key intermediate iminophosphorane was prepared from 5-aminopyrazole in the presence of triphenylphosphine and hexachloroethane. Eleven 6-alkylamino(oxy)-3-methylthio-1H-pyrazolo[3,4-d] pyrimidin-4(5H)-one derivatives were designed and synthesized via a tandem aza-Wittig reaction. The structures of target compounds were confirmed by ¹H NMR,EI-MS,IR spectroscopy and elemental analyses. The results of preliminary bioassay indicate that some compounds possess good herbicidal activity against the roots of Rape and Barnyard grass.
- aza-Wittig reaction,
- pyrazolo[3,4-d]pyrimidine,
- fungicidal activity,
- herbicidal activity
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