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Citation: FAN Ningjuan, WANG Changru, TANG Jiangjiang, GAO Jinming. Synthesis of 4'-Aminobenzylidene Derivative of Progesterone with Tin (Ⅱ) Chloride as the Reducing Agent[J]. Chinese Journal of Applied Chemistry, ;2014, 31(5): 520-523. doi: 10.3724/SP.J.1095.2014.30351 shu

Synthesis of 4'-Aminobenzylidene Derivative of Progesterone with Tin (Ⅱ) Chloride as the Reducing Agent

1.
College of Science, Northwest Agriculture and Forestry University, Yangling 712100, China

Corresponding author: TANG Jiangjiang,
Received Date: 15 July 2013
Available Online: 6 September 2013
Fund Project: 中央高校基本科研业务费专项资金(QN2012047) (QN2012047)

The 4'-nitrobenzylidene derivative 3 prepared from progesterone was reduced by SnCl₂·2H₂O/HCl to obtain 4'-aminobenzylidene derivative 4.When ethyl acetate was used as the solvent and five equivalents of SnCl₂ was used as the reducing agent,the yield was up to 74%,which provides a convenient route to synthesize amino-modified steroidal derivatives.
- progesterone,
- benzylidene steroidal derivatives,
- tin(Ⅱ) chloride
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