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Citation: DUAN Zhifang, ZHANG Shaoping, FU Li, LI Chongbi. Synthesis and Antioxidant Activities of Hesperitin Schiff Base Derivatives[J]. Chinese Journal of Applied Chemistry, ;2014, 31(5): 513-519. doi: 10.3724/SP.J.1095.2014.30345 shu

Synthesis and Antioxidant Activities of Hesperitin Schiff Base Derivatives

1.
College of Life Science, Biopharmaceutical Research and Development Center, Zhaoqing University, Zhaoqing 526061, China

Corresponding author: LI Chongbi,
Received Date: 10 July 2013
Available Online: 22 September 2013
Fund Project: 广东省科学技术厅基金项目(2011101) (2011101)肇庆市科技创新计划项目(2012G25) (2012G25)

Hesperidin was extracted from citrus peels.Hesperetin was then prepared by acid-catalyed hydrolysis reaction of hesperidin.Eighteen hesperitin Schiff base derivatives were synthesized by the condensation reaction of hesperetin with amino compounds.These compounds were characterized by UV,IR,¹H NMR,MS and elemental analysis.The scavenging effects of hesperidin,hesperitin and these Schiff base compounds on the superoxide radical(O₂^-·),hydroxyl radical(·OH) and 2,2-diphenyl-1-picrylhydrazyl radical(DPPH·) and their total reduction activities were also compared.The results show that all of the Schiff bases used herein have scavenging effects on these radicals,and some hydrazones derivatives have stronger effect than hesperidin and hesperitin at the concentration of 1.0 g/L.
- hesperidin,
- hesperitin,
- Schiff bases,
- synthesis,
- antioxidation
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