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Citation: FAN Xuemei, WANG Shumin, CUI Xiaowei. Determination of Acetaminophen in Pharmaceuticals by Luminol-H₂O₂-Silver Nanoparticle Chemiluminescence System[J]. Chinese Journal of Applied Chemistry, ;2014, 31(1): 109-113. doi: 10.3724/SP.J.1095.2014.30065 shu

Determination of Acetaminophen in Pharmaceuticals by Luminol-H₂O₂-Silver Nanoparticle Chemiluminescence System

1.
a Department of Chemistry and Chemical Engineering, Shuoluo College, Shangluo 726000, China;
2.
b Shangluo Engineering of Materials Science and Research Institute, Shangluo 726000, China

Corresponding author: FAN Xuemei,
Received Date: 25 January 2013
Available Online: 4 April 2013
Fund Project: 陕西省尾矿资源综合利用重点实验室(商洛学院) (商洛学院)陕西省科技统筹创新工程计划(2012KTDZ02-02-02)项目资助 (2012KTDZ02-02-02)

A novel method for the determination of acetaminophen was developed based on its inhibition effect on the luminol-H₂O₂-silver nanoparticle chemiluminescence system.Various factors influencing the chemiluminescence system were investigated and the possible mechanism was also studied.Under the optimum conditions,the linear range for the determination of acetaminophen is 2.0×10^-8 to 1.0×10^-4 mol/L with a detection limit of 4.0×10^-9 mol/L.The relative standard deviation is 2.6% for 1.0×10^-7 mol/L acetaminophen solution in nine repeated measurements.The method was successfully applied to the determination of acetaminophen in pharmaceutical.
- chemiluminescence,
- Ag nanoparticles,
- luminol,
- acetaminophen
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Determination of Acetaminophen in Pharmaceuticals by Luminol-H₂O₂-Silver Nanoparticle Chemiluminescence System