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Citation: DAI Peng, XIAO Yunjie, WANG Zeyu, CHEN Shikun, HE Tongsheng, SHEN Yongcun. A New Synthetic Route of N-(3-Aminopropyl) methacrylamide Hydrochloride[J]. Chinese Journal of Applied Chemistry, ;2013, 30(11): 1289-1292. doi: 10.3724/SP.J.1095.2013.30071 shu

A New Synthetic Route of N-(3-Aminopropyl) methacrylamide Hydrochloride

a. Chemical Engineering College, Wuhan University of Technology, Wuhan 430070, China;
b. Wuhan Zhibang Chemical Technology Co. Ltd., Wuhan 430070, China

Received Date: 28 January 2013
Revised Date: 2 April 2013

A new method to prepare N-(3-aminopropyl) methacrylamide hydrochloride(Ⅴ) was introduced. N-(3-Chloropropyl) methacrylamide(Ⅱ),obtained by acylation reaction between 3-chloropropylamine hydrochloride(Ⅰ) and methacrylic anhydride,was transformed via Gabriel method to N-[N'-(methacryl)-3-aminopropyl] phthalimide(Ⅲ) and hydrazinolysis product N-(3-aminopropyl) methacrylamide(Ⅳ) and then hydrochloric acidification to compound Ⅴ. The overall yield of the reaction is about 61.1%. This process does not need to use any expensive amino protection reagent,which can dramatically reduces the cost of raw materials.
- chloropropylamine hydrochloride,
- N-(aminopropyl) methacrylamide hydrochloride,
- process improvement
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