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Citation: ZHANG Feng, FANG Zheng, LI Xiaolin, HE Wei, YUAN Aibang, GUO Kai. Applications of Ugi Reaction to the Synthesis of Cyclopeptide Alkaloids,Small Peptide Antibiotics and Cytotoxins Natural Products[J]. Chinese Journal of Applied Chemistry, ;2013, 30(11): 1237-1249. doi: 10.3724/SP.J.1095.2013.30002 shu

Applications of Ugi Reaction to the Synthesis of Cyclopeptide Alkaloids,Small Peptide Antibiotics and Cytotoxins Natural Products

ZHANG Feng ^a, ,
FANG Zheng ^a ,
LI Xiaolin ^a ,
HE Wei ^a ,
YUAN Aibang ^b ,
GUO Kai ^b

a. College of Pharmaceutical Sciences, Nanjing University of Technology, Nanjing 211816, China;
b. College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 211816, China

Received Date: 4 January 2013
Revised Date: 19 April 2013

Ugi reaction is an important multicomponent reaction to yield polycondensation α-amido amide in which a molecule of aldehyde or ketone,an amine,an isocyanide and a carboxylic acid were involved.The reaction not only possesses the advantages of mild reaction condition,high yield and atom economy,but also can couple with some classical chemical reactions,for example,Suzuki,Heck and Smiles.Therefore it has attracted more and more research interest in the synthesis of natural products.The article generally summarizes the application of Ugi reaction in the synthesis of natural products in recent decades.
- Ugi reaction,
- natural products,
- synthesis
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