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Citation: DAI Yan, LV Chunxu, LI Bindong, TAN Weihong. Microwave-Assisted Synthesis of 2-(4-Hydroxy-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol via Potassium Hydroxide as the Catalyst[J]. Chinese Journal of Applied Chemistry, ;2013, 30(12): 1438-1442. doi: 10.3724/SP.J.1095.2013.20590 shu

Microwave-Assisted Synthesis of 2-(4-Hydroxy-phenyl)-1,1,1,3,3,3-hexafluoro-propan-2-ol via Potassium Hydroxide as the Catalyst

DAI Yan ^a,b, ,
LV Chunxu ^c ,
LI Bindong ^c ,
TAN Weihong ^a,b

a. Institute of Chemical Industry of Forest Products, CAF;National Engineering Laboratory for Biomass Chemical Utilization, Key and Open Laboratory on Forest Chemical Engineering, SFA;Jiangsu Province Key Laboratory of Biomass Energy and Material, Nanjing 210042, China;
b. Institute of Forest New Technology, CAF, Beijing 100091, China;
c. College of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China

Received Date: 17 December 2012
Revised Date: 7 May 2013

With the assistance of microwave,a mixture of 2-(4-hydroxy-phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol isomers were obtained via the condensation between hexafluoroacetone trihydrate (HFA·3H₂O) and phenol using potassium hydroxide as catalyst. The product was characterized by ¹H NMR,IR and MS spectra. The results show that the microwave-assisted process can reduce the reaction time remarkably compared with conventional processes. Under optimal conditions with the microwave power 300 W at n(phenol):n (HFA·3H₂O):n (KOH)=3.0:1.0:0.3,the reaction time are shortened from 35 h in conventional heating to 6 h,the total yield is increased from 87% to 90% with 94% selectivity.
- (hydroxy-phenyl)-hexafluoro-propan-ol,
- phenol,
- microwave,
- potassium hydroxide,
- hexafluoroacetone trihydrate,
- orthogonal experimental design
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