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Citation: LIU Ju, JING Chunyan, WANG Yang, TENG Pengfei, XU Jiatong, XU Lifeng. Synthesis of 3,6-Diarylpyrazolo[1,5-a]pyrimidines[J]. Chinese Journal of Applied Chemistry, ;2013, 30(12): 1494-1496. doi: 10.3724/SP.J.1095.2013.20574 shu

Synthesis of 3,6-Diarylpyrazolo[1,5-a]pyrimidines

College of Pharmacy, Liaoning University, Shenyang 110036, China

Received Date: 10 December 2012
Revised Date: 6 March 2013

Twelve new 7-substituted-3,6-diarylpyrazolo[1,5-a]pyrimidines were synthesized by the aminizations of the derivatives of 5,7-dichloro-3-(2,4-dichlorophenyl)-2-methyl-6-phenylpyrazolo[1,5-a]pyrimidine. These derivatives were prepared by the reaction of 3-(2,4-dichlorophenyl)-2-methyl-6-phenylpyrazolo[1,5-a]pyrimidine-5,7-diol and phosphorus oxychloride. The products were characterized by IR,¹H NMR,elemental analysis and single crystal X-ray diffraction analysis.
- pyrazolo[1,5-a]pyrimidine,
- chlorination,
- aminization,
- crystal structure
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