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Citation: LI Yuanxiang, CHEN Dizhao. Synthesis and Biological Activities of N-(2-(Cyano(4,6dimethoxypyrimidin-2-yl) methyl) phenyl) Substitued Amide Derivatives[J]. Chinese Journal of Applied Chemistry, ;2013, 30(9): 999-1004. doi: 10.3724/SP.J.1095.2013.20541 shu

Synthesis and Biological Activities of N-(2-(Cyano(4,6dimethoxypyrimidin-2-yl) methyl) phenyl) Substitued Amide Derivatives

LI Yuanxiang ^a,b, ,
CHEN Dizhao ^a

a. Chemistry and Chemical Engineering Department, Huaihua University, Huaihua 418008, China;
b. Key Laboratory of Pesticide & Chemical Biology, Education of Ministry, College of Chemistry, Central China Normal University, Wuhan 430079, China

Received Date: 22 November 2012
Revised Date: 31 December 2012

Six novel N-(2-(cyano(4,6-dimethoxypyrimidin-2-yl) methyl) phenyl) substitued amide derivatives were synthesized using 2-(2-nitrophenyl) acetonitrile and 4,6-dimethoxy-2-(methylsulfonyl) pyrimidine as starting materials by condensation reaction,reduction reaction and acylation reaction,respectively. The structures of all synthesized compounds were determined by ¹H NMR,MS and elemental analysis techniques. As-synthesized compounds did not show herbicidal activities at 150 g/hm². The antibacterial activity test indicated that some of them exhibited certain inhibitory activities against Sphaerotheca fuliginea and Rhizoctonia solani, respectively at 200 mg/L. The inhibition rate of compound 4d against Rhizoctonia solani was 72.3% at 200 mg/L.
- pyrimidinylsalicylic acid,
- dimethoxypyrimidine,
- amide,
- synthesis,
- biological activities
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