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Citation: ZHU Yizhong, ZHANG Xiquan, LIU Fei, GU Hongmei, ZHU Hailiang. A New Synthetic Route Toward o-Chlorobenzonitrile[J]. Chinese Journal of Applied Chemistry, ;2013, 30(8): 971-973. doi: 10.3724/SP.J.1095.2013.20530 shu

A New Synthetic Route Toward o-Chlorobenzonitrile

a. Jiangsu Chiatai Tianqing Pharmaceutical Co. Ltd., Nanjing 210042, China;
b. State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China

Received Date: 16 November 2012
Revised Date: 30 January 2013

o-Chlorobenzonitrile was prepared from the cyanization reaction of o-chlorobromobenzene using potassium ferrocyanide as cyanating agent and Pd/C as a catalyst. The reaction conditions were optimized through investigating the reaction temperature,base,the amount of catalyst,the ratio of reactants. The conversion of the o-chlorobromobenzene to target product could reach 98.5% and the yield of o-chlorobenzonitrile was 95.1%.
- o-chlorobromobenzene,
- potassium ferrocyanide,
- cyanization reaction
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