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Citation: JAING Fuxiang, LIU Qiaozhen, WANG Guo, CHEN Heru. Synthesis of Piperidine Derivatives from 1,5-Diols[J]. Chinese Journal of Applied Chemistry, ;2013, 30(7): 769-775. doi: 10.3724/SP.J.1095.2013.20516 shu

Synthesis of Piperidine Derivatives from 1,5-Diols

a. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China;
b. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Ji'nan University, Guangzhou 510632, China

Received Date: 12 November 2012
Revised Date: 25 March 2013

A series of piperidine derivatives was synthesized using 1,5-diols as starting materials. The procedures include the sulfonylation of 1,5-diols to active 1,5-disulfonates followed by the cyclization of the 1,5-disulfonates with primary amines. The effects of reaction temperature,time on the annulation were further explored. It was disclosed that when the solvent was primary amine,reaction temperature was 90~100℃,and reaction time was 18 h,the yields of 74%~94% for annulations could be reached.
- diols,
- piperidine,
- iminosugar,
- organic synthesis
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