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Citation: AN Yue, HAN Jie, ZHANG Ting, FENG Hui, ZHOU Xiaoxia. Synthesis and Biological Activities of 2-{[5'-Methyl(H) benzoimidazol-2'-yl]methylthio}-5-substituted-1,3,4-oxadiazole Derivatives[J]. Chinese Journal of Applied Chemistry, ;2013, 30(8): 872-877. doi: 10.3724/SP.J.1095.2013.20458 shu

Synthesis and Biological Activities of 2-{[5'-Methyl(H) benzoimidazol-2'-yl]methylthio}-5-substituted-1,3,4-oxadiazole Derivatives

AN Yue ^a, ,
HAN Jie ^a ,
ZHANG Ting ^a ,
FENG Hui ^b ,
ZHOU Xiaoxia ^a

a. College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China;
b. Analysis and Inspection Center, Liaoning Normal University, Dalian 116029, China

Received Date: 12 October 2012
Revised Date: 5 January 2013

Two kinds of 2-chloromethyl-benzimidazole were synthesized by substituted o-diaminobenzene and monochloroacetic acid in hydrochloric acid solution. With substituted carboxylic acid as the starting materials,ten kinds of 1,3,4-oxadiazoles were prepared via esterification,hydrazinolysis,followed by reaction with carbon disulfide in potassium hydroxide solution. At last,fourteen new target compounds were synthesized by reacting 5-substituted-1,3,4-oxadiazole-3-thiol with 2-chloromethyl-5-substituted-bezoimidazole in sodium hydroxide solution. The structures of all the compounds were characterized by IR,¹H NMR and elemental analysis. Preliminary biological activity experiments showed that the synthesized compounds had certain effects on the wheat gemma and germination of mung bean.
- benzoimidazole,
- oxadiazole,
- synthesis,
- biological activity
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