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Citation: CHEN Shilan, LIU Mingzhu, LU Shaoyu, JIN Shuping, CHEN Yong. Preparation and Drug Release Behavior of Chitosan Grafted Poly(methacrylic acid) Gel Bead[J]. Chinese Journal of Applied Chemistry, ;2013, 30(3): 252-259. doi: 10.3724/SP.J.1095.2013.20188 shu

Preparation and Drug Release Behavior of Chitosan Grafted Poly(methacrylic acid) Gel Bead

CHEN Shilan ^a,b, ,
LIU Mingzhu ^b ,
LU Shaoyu ^b ,
JIN Shuping ^b ,
CHEN Yong ^b

a. College of Chemistry and Chemical Engineering, Chongqing University of Science & Technology, Chongqing 401331, China;
b. College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China

Received Date: 10 May 2012
Revised Date: 2 July 2012

Chitosan grafted poly(methacrylic acid)(CS-g-PMAA) was synthesized using methacrylic acid and chitosan as precursors and cerium ammonium nitrate as initiator.Products with different grafting degree were characterized by means of FTIR,¹H NMR and elemental analysis.Drug-loaded beads made from the as-prepared copolymers were fabricated by combining ionic-crosslink with chemical-crosslink using trisodium citrate and glutaraldehyde as crosslinking agent,respectively.The beads have a core-shell structure as revealed from scanning electron microscopy.The release behaviors of model drug incorporated in the beads were monitored using UV/Vis spectrophotometer and found to be dependent on pH and NaCl content.The results show that the drug release rate is slowest for CS-g-PMAA beads with grafting fraction (G_g) of 12.21%.The total drug release fraction for the CS-g-PMAA beads is 44.18% at pH=1.8 and is less than that of CS beads,which is 65.24%.Therefore,the grafting of CS could improve the drug release behavior.In addition,CS-g-PMAA beads have higher enzymatic stability than that of CS beads.
- chitosan,
- methacrylic acid,
- graft copolymerization,
- drug release,
- core-shell structure
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