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Citation: XU Suoping, LU Han, XU Jinhong. Microwave Synthesis,Crystal Structure and Antibacterial Activities of 5-Chlorosalicylaldehyde-2aminoethanol-copper(Ⅱ)[J]. Chinese Journal of Applied Chemistry, ;2013, 30(3): 295-299. doi: 10.3724/SP.J.1095.2013.20150 shu

Microwave Synthesis,Crystal Structure and Antibacterial Activities of 5-Chlorosalicylaldehyde-2aminoethanol-copper(Ⅱ)

XU Suoping ^a,b, ,
LU Han ^b ,
XU Jinhong ^b

a. School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou 221008, China;
b. Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou 221116, China

Received Date: 13 April 2012
Revised Date: 20 August 2012

5-Chlorosalicylaldehyde-2-aminoethanol-copper(Ⅱ) was synthesized using 5-chlorosalicylaldehyde,2-aminoethanol and cupric chloride as precursors under microwave irradiation. The product was characterized by IR spectra,elemental analysis and single X-ray crystallography study. The title complex crystallizes in the monoclinic space group P2₁/n. Cell parameters:a=0.49793(6) nm,b=1.7037(2) nm,c=1.07120(12) nm,β=94.579(3)°,F(000)=470,Z=2,V=0.905(8) nm³,D_c=1.689 mg/m³,R[I>2σ(I)],R₁=0.0624,ωR₂=0.1555. The Cu(Ⅱ) adopts a square planar configuration coordinated by two nitrogen atoms and two oxygen atoms from two Schiff bases. The antibacterial (B.subtilis, S.aureus, S.faecalis, P.aeruginosa, E.coli and E.cloacae) activities of the compounds were assayed by MTT (3-(4,5-dimethylthiazol-2-yl) -2,5-diphenyl tetrazolium bromide) method. It showed favorable antimicrobial activity with minimal inhibitory concentrations(MICs) of 12.25,25,12.5,12.5,6.25 and 6.25 mg/L against B.subtilis, S.aureus, S.faecalis, P.aeruginosa, E.coli and E.cloacae, respectively.
- chlorosalicylaldehyde-aminoethanol-copper(Ⅱ),
- microwave synthesis,
- crystal structure,
- antibacterial activities
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