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Citation: CHEN Yongshi, LIN Jianguo, QIU Ling, CHENG Wen, LUO Shineng, MA Haixia. Synthesis and Characterization of Phenylmethanesulfonamide Ligand for Potential Labeling [^99mTc(CO)₃(H₂O)₃]⁺[J]. Chinese Journal of Applied Chemistry, ;2012, 29(7): 757-761. doi: 10.3724/SP.J.1095.2012.00333 shu

Synthesis and Characterization of Phenylmethanesulfonamide Ligand for Potential Labeling [^99mTc(CO)₃(H₂O)₃]⁺

CHEN Yongshi ^a,b ,
LIN Jianguo ^b,, ,
QIU Ling ^b ,
CHENG Wen ^b ,
LUO Shineng ^b ,
MA Haixia ^a,,

1.
a School of Chemical Engineering, Northwest University, Xi'an 710069, China;
2.
b Key Laboratory of Nuclear Medicine of Ministry of Healthy, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063

Corresponding author: LIN Jianguo, MA Haixia,
Received Date: 25 July 2011
Available Online: 21 October 2011
Fund Project: 国家自然科学基金(20801024,21001055)资助项目 (20801024,21001055)江苏省卫生厅科研项目(H200963) (H200963)

A new ligand N-[2-cyclohexylmethoxy-4(1-(2,2'-bipyridinemethyl)amino)acetylamino] phenylmethanesulfonamide(NSC-PA),for potential labeling [^99mTc(CO)₃(H₂O)₃]⁺ was synthesized by hydroxyl-alkylation,amino-methylsulfonylation,nitro-reduction,amino-bromideacetylation and N-alkylation from 2-amino-5-nitrophenol.Simple experimental operation,short period and purified products could be obtained under optimized conditions.The structures of all the compounds were confirmed by ¹H NMR,IR and MS.The purity of the target compound was over 98% as given by HPLC result.The target product could be used for future labeling studies.This synthesis is promising in the exploration of new imaging reagent for breast cancer.
- phenylmethanesulfonamide,
- synthesis,
- characterization,
- labeling ligand
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Synthesis and Characterization of Phenylmethanesulfonamide Ligand for Potential Labeling [99mTc(CO)3(H2O)3]+

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Synthesis and Characterization of Phenylmethanesulfonamide Ligand for Potential Labeling [^99mTc(CO)₃(H₂O)₃]⁺