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Citation: WEN Wen, GAO Xiaoya, ZHANG Aiping, SONG Zhiying, SUN Yanping. Effects of Nano-TiO₂ Photocatalytic Oxidization on the Cell Cycle of BGC-823 Gastric Cancer Cells[J]. Chinese Journal of Applied Chemistry, ;2012, 29(6): 663-667. doi: 10.3724/SP.J.1095.2012.00324 shu

Effects of Nano-TiO₂ Photocatalytic Oxidization on the Cell Cycle of BGC-823 Gastric Cancer Cells

1.
a School of Pharmacy, Shanxi Medical University, Taiyuan 030001, China;
2.
b Institute of Clean Technique for Chemical Engineering of Taiyuan University of Technology, Taiyuan 030024, China

Corresponding author: ZHANG Aiping,
Received Date: 22 July 2011
Available Online: 25 September 2011
Fund Project: 山西省自然科学基金(2010011048-1) (2010011048-1)山西医科大学科技创新基金(01200806)资助项目 (01200806)

In order to explore the mechanisms of killing cancer cells via nano-TiO₂ photocatalytic oxidization,gastric cancer cell line BGC-823 was cultured as research object in this study.The morphologic changes were observed by inverted phase-contrast microscope,the apoptotic rates and cell cycle of BGC-823 cells were examined by flow cytometer.The results showed that nano-TiO₂ photocatalytic oxidation caused the necrosis or secondary necrosis of BGC-823 cells,and inhibited the synthesis of DNA and their proliferation process,through arresting the G₂/M phase and inducing apoptosis of BGC-823 cells.Significant arrest was observed and the apoptotic rates of BGC-823 cells reached 24.34% when the coated amount of TiO₂ was 9.8×10^-7 g/cm² and the irradiation time was 40 min.
- photocatalytic oxidization,
- nano-TiO₂,
- gastric cancer cell line BGC-823,
- cell cycle,
- apoptosis
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沈阳化工大学材料科学与工程学院沈阳 110142

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通讯作者: 陈斌, bchen63@163.com

Effects of Nano-TiO₂ Photocatalytic Oxidization on the Cell Cycle of BGC-823 Gastric Cancer Cells