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Citation: LIU Qian, QIAN Jing, WANG Kun, LI Yeping, WU Xiangyang. pH Sensitivity of Monomethoxypoly(ethylene glycol)grafted-chitosan and Its Controlled Delivery of Cytochrome c via Electrochemical Method[J]. Chinese Journal of Applied Chemistry, ;2012, 29(3): 340-345. doi: 10.3724/SP.J.1095.2012.00197 shu

pH Sensitivity of Monomethoxypoly(ethylene glycol)grafted-chitosan and Its Controlled Delivery of Cytochrome c via Electrochemical Method

LIU Qian ^a ,
QIAN Jing ^a ,
WANG Kun ^a,, ,
LI Yeping ^b ,
WU Xiangyang ^a

1.
a School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China;
2.
b School of Pharmacy, Jiangsu University, Zhenjiang 212013, China

Corresponding author: WANG Kun,
Received Date: 11 May 2011
Available Online: 21 June 2011
Fund Project: 国家自然科学基金(20875039和21075054) (20875039和21075054)现代农业装备与技术省部共建教育部重点实验室开放基金(NZ200809) (NZ200809)江苏大学高级人才基金(06JDG016)资助项目 (06JDG016)

A pH-sensitive monomethoxypoly(ethylene glycol)-grafted-chitosan(mPEG-g-CS) film was used as a matrix for reversible immobilization of cytochrome c(Cyt c) on a Au surface through a novel electrodeposition process.The pH-sensitive behavior of the mPEG-g-CS film was demonstrated by cyclic voltammetry(CV) and electrochemical impedance spectroscopy(EIS) measurements.Electrochemical co-deposited Cyt c and mPEG-g-CS exhibited the direct electrochemical behavior which implied that mPEG-g-CS could well control the delivery of Cyt c under different pH.
- monomethoxypoly(ethylene glycol)-grafted-chitosan,
- pH sensitivity,
- cytochrome c,
- direct electrochemistry,
- controlled delivery
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