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Citation: SHAN Zhenguo, XUE Sijia. Synthesis and Anti-tumor Activity of N-(Substituted benzyl)-3, 5-bis(benzylidene)-4-piperidones[J]. Chinese Journal of Applied Chemistry, ;2012, 29(2): 144-148. doi: 10.3724/SP.J.1095.2012.00126 shu

Synthesis and Anti-tumor Activity of N-(Substituted benzyl)-3, 5-bis(benzylidene)-4-piperidones

SHAN Zhenguo ,
XUE Sijia ^,

1.
Department of Chemistry, College of Life and Environmental Science, Shanghai Normal University, Shanghai 200234, China

Corresponding author: XUE Sijia,
Received Date: 28 March 2011
Available Online: 13 June 2011
Fund Project: 国家自然科学基金(201042010) (201042010)上海市教委重点科技攻关项目(09391212100)资助项目 (09391212100)

A series of novel N-(substituted benzyl)-3,5-bis(benzylidene)-4-piperidones(8a~8j) were synthesized uisng substituted benzylamines as precursors via a series of Michael addition,Dieckmann condensation,hydrolysis decarboxylation and Aldol condensation.The structures were confirmed by ¹H NMR,IR,MS and elemental analysis.The preliminary biological activity tests by MTT assay indicated that some of the target compounds had good antiproliferative activities against K562,MDR-MB-231 and HO8910PM cells,and therefore showed potential anti-tumors bioactivity.
- N-substituted-piperidone,
- synthesis,
- anti-tumor,
- MTT assay
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