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Citation: HU Bingcheng, LIANG Changyu, LU Ming, DAI Hongsheng, SUN Chengguo, XU Shichao. A New Synthetic Route to 3, 5-Diaminopyridine and 3, 5-Dimethoxycarbonylamino-pyridine[J]. Chinese Journal of Applied Chemistry, ;2012, 29(1): 80-83. doi: 10.3724/SP.J.1095.2012.00065 shu

A New Synthetic Route to 3, 5-Diaminopyridine and 3, 5-Dimethoxycarbonylamino-pyridine

1.
School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094

Corresponding author: HU Bingcheng,
Received Date: 21 February 2011
Available Online: 13 April 2011
Fund Project: 国家部委基金(HZY09020302-7)资助项目 (HZY09020302-7)国家自然科学基金委员会和中国工程物理研究院联合基金资助项目(11076017) (11076017)

3,5-Diaminopyridine and 3,5-dimethoxycarbonylamino-pyridine were prepared from 3,5-dimethylpyridine in three steps including oxidation of methyl,amination and Hofmann degradation with the total yield of 64% and 68%,respectively.The reaction conditions of every step were studied and the intermediates and target compounds were characterized by ¹H NMR,MS/MS,and IR.The reactions proceed under atmosphere pressure with mild reaction conditions,easy post treatment and high efficiency.
- dimethylpyridine,
- Hofmann degradation,
- diaminopyridine,
- dimethoxycarbonylamino-pyridine
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