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Citation: DONG Lijuan, YAO Qizhi, MA Fang, JIN Gu. Facile Preparation and Application of Silica-Alginate Microsphere[J]. Chinese Journal of Applied Chemistry, ;2011, 28(6): 678-682. doi: 10.3724/SP.J.1095.2011.00458 shu

Facile Preparation and Application of Silica-Alginate Microsphere

1.
Department of Chemistry, University of Science and Technology of China, Hefei 230026

Corresponding author: JIN Gu,
Received Date: 5 August 2010
Available Online: 6 December 2010
Fund Project: 国家自然科学基金(29405038)资助项目 (29405038)

Hollow inorganic particles have attracted great interest because of their unique physicochemical properties.In this study,a simple and effective method for synthesizing silica hollow spheres is presented.The synthesis utilizes CaCO₃ as spherical templates for the silica growth;tetraethyl orthosilicate(TEOS) is added to the template as a precursor for the silica formation.After CaCO₃ spherical cores were removed by adding diluted hydrochloric acid,hollow silica spheres with smooth surface and uniform shell thickness around 60~70 nm were obtained.The core shell structure of CaCO₃ sphere-silica composites and the hollow structure of silica spheres were characterized by FESEM,TEM,TGA,XRD and FTIR.The results indicated that the silica was coated on the surface of CaCO 3 spheres.The inner diameter of the hollow silica spheres with amorphous shell was about 1~2 μm.Amine functional silica hollow spheres were prepared via the hydrolysis of APTMs,then alginate was firstly grafted onto the surface of amine silica then the alginate coating was immobilized by gelling Ca²⁺ ions and alginate,which allows the formation of alginate-modified hollow SiO₂.The size of microsphere is about 1~2 μm.Daunorubicin as a probing drug was loaded into the carrier,the maximum percent of envelop and load were 55.6% and 27.8% respectively.
- CaCO₃,
- hollow SiO₂,
- alginate,
- microsphere,
- daunorubicin
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