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Citation: LIU Chuanyin, HU Jiming. Recent Advance of Affinitive Biosensors in Biomedical Applications[J]. Chinese Journal of Applied Chemistry, ;2011, 28(6): 611-623. doi: 10.3724/SP.J.1095.2011.00455 shu

Recent Advance of Affinitive Biosensors in Biomedical Applications

LIU Chuanyin ^a,b ,
HU Jiming ^b,,

1.
a College of Chemical Engineering and Food Science, Xiangfan University, Xiangyang;
2.
b Key Laboratory of Analytical Chemistry for Biology and Medicine(Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072

Corresponding author: HU Jiming,
Received Date: 5 August 2010
Available Online: 2 November 2010
Fund Project: 湖北省教育厅优秀中青年项目(Q200760001) (Q200760001)十堰市科技计划及开发项目(2010nt05)资助 (2010nt05)

Biosensors have received vigorous development and serious concern in recent years owing to the combinations with nanotechniques,flow-injection and micro-fluidics devices.Affinitive biosensor is a kind of high-tech sensing device based on the specific affinity between biological molecules,and the affinity of bioactive substance and substrate.With the advantages of high specificity,good sensitivity,high speed,low cost,on-line measuring and monitoring in complicated system,affinitive biosensors are widely used in biomedical fields,such as the detection of biomedical markers,nucleic acids,proteins,viruses,bacteria and toxins,the research of medicine actions mechanism,clinical drug screening,and etc.In this paper,the recent advance of affinitive biosensors in biomedical applications are reviewed.We also focus on a growing number of applications and progress in immunosensors and aptamer-based biosensors for tumor biomarker,nucleic acids and proteins.It covers the basic principles and biomedical and clinical applications of immunosensors and aptamer-based biosensors,and indicates the future prospects in this field.
- affinity biosensor,
- immunosensor,
- tumor biomarker,
- aptamer-based biosensor,
- biomedical application
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