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Citation: DONG Yan, LIU Zuliang, YUAN Chengliang. A New Synthetic Route to 5-Amino-6-nitro-[1,2,5]oxadiazolo[3,4-b]pyridine-1-oxide[J]. Chinese Journal of Applied Chemistry, ;2011, 28(5): 521-525. doi: 10.3724/SP.J.1095.2011.00402 shu

A New Synthetic Route to 5-Amino-6-nitro-[1,2,5]oxadiazolo[3,4-b]pyridine-1-oxide

1.
Chemical Engineering School, Nanjing University of Science & Technology, Nanjing 210094

Corresponding author: LIU Zuliang,
Received Date: 9 July 2010
Available Online: 11 October 2010

A new synthetic route to 5-amino-6-nitro-[1,2,5] oxadiazolo [3,4-b] pyridine-1-oxide was developed using 2,6-dichloropyridine as starting materials via four steps,including hydrazinolysis,reduction,nitration and Nietzki-Dietschy cyclization.The effects of these reactions were investigated based on their reaction mechanisms.On the basis of these results,the reaction was optimized and the overall yield of target product was up to 59.2%.The product was characterized by ¹HNMR,MS and IR.
- dichloropyridine,
- amino,
- nitro-[1,2,5]oxadiazolo[3,4-b]pyridine-oxide,
- hydroxylamine hydrochloride,
- super acid nitration,
- Pd/C-H₂ reduction
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