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Citation: WU Tong, TAN Chao, WANG Jinyue. Capillary Electrophoresis Determination of the Enantiomeric Purity of Four Compounds Obtained from Asymmetry Synthesis[J]. Chinese Journal of Applied Chemistry, ;2011, 28(4): 486-488. doi: 10.3724/SP.J.1095.2011.00377 shu

Capillary Electrophoresis Determination of the Enantiomeric Purity of Four Compounds Obtained from Asymmetry Synthesis

1.
School of Chemistry and Chemical Engineering, Yibin University, Yibin 644000

Corresponding author: WU Tong,
Received Date: 28 June 2010
Available Online: 15 September 2010
Fund Project: 四川省青年科学基金(09ZQ026-066) (09ZQ026-066)宜宾学院基金(2010B13)资助项目 (2010B13)

The enantioseparation of four compounds,3-(diethylamino)-1-phenylpropan-1-ol(a),1-phenyl-3-(piperidin-1-yl) propan-1-ol(b),3-morpholino-1-p-tolypropan-1-ol(c) and 1-(4-chlorophenyl)-3-morpholinopropan-1-ol(d),obtained from asymmetry synthesis,was studied by capillary electrophoresis using α-cyclodextrin,β-cyclodextrin and β-cyclodextrin polymer as chiral selectors.With 20 kV as the separation voltage,and 30 g/L β-cyclodextrin polymer in 80 mmol/L Tris(pH=3.2) as background electrolyte solution,four chiral compounds were enantioseparated in 40 min.The enantiomeric purity of these four chiral compounds was determined according to the ratio of peak area with RSD no more than 1.5%.
- capillary electrophoresis,
- enantiomeric purity,
- β-cyclodextrin polymer,
- enantioseparation
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