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Citation: FENG Xiaoqiang, LI Xiaofang, YANG Sheng. Preparation， Antibacterial Activities of Thiourea-chitosanCo(Ⅱ) Complex and Interaction with Bovine Serum Albumin[J]. Chinese Journal of Applied Chemistry, ;2011, 28(9): 1012-1016. doi: 10.3724/SP.J.1095.2011.00375 shu

Preparation， Antibacterial Activities of Thiourea-chitosanCo(Ⅱ) Complex and Interaction with Bovine Serum Albumin

1.
College of Life Science and Chemistry, Tianshui Normal University, Tianshui 741001

Corresponding author: FENG Xiaoqiang,
Received Date: 28 June 2010
Available Online: 10 October 2010
Fund Project: 甘肃天水师范学院"青蓝"人才工程及物理无机化学重点学科基金资助项目(ZD0840) (ZD0840)

Thiourea-chitosan-Co(Ⅱ) complex was prepared and characterized by FT-IR, UV-Vis absorbance spectra and TG-DTA methods, the antibacterial activities of thiourea-chitosan-Co(Ⅱ) complex against E.coli and St. aureus were studied in vitro. Moreover, the interaction between thiourea-chitosan-Co(Ⅱ) complex and bovine serum albumin(BSA) was also studied by ultraviolet and fluorescence spectroscopies. The results confirm that the complex is formed, and the antibacterial activities of thiourea-chitosan-Co(Ⅱ) complex is obviously enhanced comparing to its ligands and the complex can quench the intrinsic fluorescence of BSA.
- thiourea-chitosan-Co(Ⅱ) complex,
- antibacterial activity,
- bovine serum albumin
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