Citation:
WANG Rulin, JIANG Hongyan, QIN Shuzhu, WANG Peng. Inclusions of Lornoxicam by β-Cyclodextrin and Its Derivatives[J]. Chinese Journal of Applied Chemistry,
;2011, 28(4): 421-425.
doi:
10.3724/SP.J.1095.2011.00358
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The inclusions of lornoxicam(LX) by β-cyclodextrin(β-CD),hydroxypropyl-β-cyclodextrin(HP-β-CD),and sulfobutyl ether-β-cyclodextrin(SBE-β-CD) were studied by fluorescence spectroscopy,differential scanning calorimetry(DSC) and NMR at different pH and temperature.The results showed that the 1:1 inclusion compounds were formed between lornoxicam and CDs.Based on the formation constants,the interactions between lornoxicam and the three CDs follow an order of SBE-β-CD >HP-β-CD >β-CD.
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Keywords:
- lornoxicam,
- β-cyclodextrin,
- fluorescence spectroscopy,
- DSC,
- NMR
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