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Citation: CHEN Guanhong, WANG Jianing, KONG Xue, LIU Kechun. Synthesis and Anti-tumor Activity of 1-(4-Chloroaniline)-4-(4-pyridylmethyl)-2,3-Benzodiazine Succinate[J]. Chinese Journal of Applied Chemistry, ;2011, 28(12): 1375-1378. doi: 10.3724/SP.J.1095.2011.00006 shu

Synthesis and Anti-tumor Activity of 1-(4-Chloroaniline)-4-(4-pyridylmethyl)-2,3-Benzodiazine Succinate

1.
Key Laboratory of Applied Microbiology of Shandong Province, Biology Institute of Shandong Academy of Sciences, Jinan 250014

Corresponding author: WANG Jianing,
Received Date: 6 January 2011
Available Online: 23 March 2011
Fund Project: 山东省国际合作资助项目(2008GJHZ10201) (2008GJHZ10201)

1-(4-Chloroaniline)-4-(4-pyridylmethyl)-2,3-benzodiazine succinate(4) was synthesized by addition,rearrangement,substitution and halogenesis steps with phthalide and 4-pyridinecarbaldehydes as starting reagents.The intermediate and target compound 4 were characterized by ¹H NMR,MS and HPLC.After purification by recrystallization,the compound 4(98.1% purity estimated by HPLC) was experimentally used to treat colorectal cancer nude mice.The result shows that this compound obviously restrains the growth of tumors.
- chloroaniline(pyridylmethyl) benzodiazine succinate,
- synthesis,
- anti-tumor activity
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