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Citation: WANG Yin-Ning, ZHAO Bai-Jin, LI Liang-Bin. Interaction between Trehalose and Ceramide Studied by in-situ X-ray Scattering[J]. Chinese Journal of Applied Chemistry, ;2010, 27(10): 1149-1155. doi: 10.3724/SP.J.1095.2010.90878 shu

Interaction between Trehalose and Ceramide Studied by in-situ X-ray Scattering

National Synchrotron Radiation Laboratory and College of Nuclear Science and Technology, University of Science and Technology of China, Hefei 230029

Received Date: 25 December 2009
Revised Date: 5 March 2010

Trehalose and ceramide both play important roles in retaining skin water. With an X-ray scattering instrument,we studied the interaction between ceramide E and trehalose systematically in the course of drying and heating-cooling scan. It was found that ceramide E,similar to lipids in membrane,was difficult to crystallize in the presence of trehalose.Similarly,ceramide also suppresses the crystallization of trehalose during drying and therefore prevents water loose. Furthermore,after cooling from 105℃ to room temperature with the presence of trehalose,the freeze-dried ceramide formed a structure similar to that of stratum corneum in human skin in which both liquid and orthorhombic crystal exist. It is the first time to be found that trehalose,in stead of other components in skin,help ceramide to be organized by the form in the real human skin.
- trehalose,
- ceramide,
- X-ray diffraction,
- skin
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