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Citation: CHENG Qing-Fang, XU Xing-You, WANG Qi-Fa, LIN Qiao, LIU Wang-Jun, YANG Xu-Jie. One-step Synthesis of 4-Chlorophenyl Isoferulate under Ultrasonic Irradiation[J]. Chinese Journal of Applied Chemistry, ;2010, 27(5): 618-620. doi: 10.3724/SP.J.1095.2010.90527 shu

One-step Synthesis of 4-Chlorophenyl Isoferulate under Ultrasonic Irradiation

a. Deparment of Chemical Technology, Huaihai Institute of Technology, Lianyungang 222005;
b. Materials Chemistry Laboratory, Nanjing University of Science and Technology, Nanjing 210094

Received Date: 10 August 2009
Revised Date: 28 September 2009

4-Chlorophenyl isoferulate was synthesized in one-step from isoferulic acid and 4-chlorophenol without the protection of the hydroxyl of isoferulic acid in the presence of 4-dimethylpyridine(DMAP) as catalyst and dicyclohexylcarbodiimide(DCC) as dehydrating agent under ultrasonic irradiation at room temperature. When reactants were mixed in a n(isoferulic acid):n(4-chlorophenol):n(DCC):n(DMAP)=1:1.2:1.2:0.1, and exposed to ultrasonic irradiation for 2.5 h, the yield was 76.2%. The structure of the product was confirmed by elemental analysis, ¹H NMR and IR. This method avoids the long reaction time and increases the yield compared with traditional synthetic method.
- chlorophenyl isoferulate,
- dicyclohexylcarbodiimide,
- dimethylpyridine,
- ultrasonic irradiation
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