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Citation: LIAO Quan-Bin, LIU Ming-Guo, CHEN Bai-Ling, DING Ming-Wu. Synthesis and Bacteriostatic Activities of 3-Phenyl-thienopyrimidin-4-ones[J]. Chinese Journal of Applied Chemistry, ;2010, 27(5): 533-538. doi: 10.3724/SP.J.1095.2010.90454 shu

Synthesis and Bacteriostatic Activities of 3-Phenyl-thienopyrimidin-4-ones

a. Hubei Provincial Key Laboratory of Natural Products Research and Development, College of Chemistry & Life Science, China Three Gorges Universtry, Yichang 443002;
b. Key Laboratory of Pesticide & Chemical Biology, Ministry of Eduction, College of Chemistry, Central China Normal University, Wuhan

Received Date: 13 July 2009
Revised Date: 17 September 2009

Thirteen new 2-aryloxy-3-phenyl-3, 5, 6, 7-tetrahydro-4H-cyclopenta[4, 5]thieno[2, 3-d]pyrimidin-4-ones were synthesized in 63%~78% yields via the aza-Wittig reaction of (4,5,6-trihydrocyclopentathiophen-2-ylimino) (triphenyl) phosphorane with phenyl iso-cyanate, and subsequent reaction with phenols. Their structures were confirmed by IR,¹H NMR, MS and elemental analysis. The bacteriostatic activities of the new compounds were tested. The results show that bacteriostatic activities of the compounds against fungus (Penicillium citrinum Thom) are better than those against bacteria.
- thienopyrimidinone,
- aza-Wittig reaction,
- synthesis,
- bacteriostatic activity
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