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Citation: HUANG Zhong-Jinga, YANG Run-Yunb, GUO Zhi-Yongb, SHE Zhi-Gangb, LIN Yong-Cheng. New Anthraquinone Derivative Produced by Cultivation of Mangrove Endophytic Fungus Fusarium sp. ZZF60 from the South China Sea[J]. Chinese Journal of Applied Chemistry, ;2010, 27(4): 394-397. doi: 10.3724/SP.J.1095.2010.90377 shu

New Anthraquinone Derivative Produced by Cultivation of Mangrove Endophytic Fungus Fusarium sp. ZZF60 from the South China Sea

a. College of Chemistry and Ecology Engineering, Guangxi University for Nationalities, Nanning;
b. School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275;
c. School of Chemistry and Chemical Engineering, Guangxi Normal University, Guilin;
d. College of Chemisitry and Life Science, China Three Gorges University, Yichang

Received Date: 4 June 2009
Revised Date: 16 August 2009

A new anthraquinone derivative,6,8-dimethoxy-1-methyl-2-(3-oxobutyl) anthrakunthone(1),together with five known compounds,7-hydroxy-3-(4-methoxyphenyl)-chromen-4-one(2),2,4-dihydroxy-6-[(1'E,3'E)-penta-1',3'-dienyl]-benzaldehyde(3),(E)-4hydroxycinnamic acid methyl ester(4),4-(4-hydroxyphenyl)-butan2-ol(5),and 4-hydroxybenzoic acid(6),were isolated from the marine mangrove endophytic fungus Fusarium sp.ZZF60 from the South China Sea.Their structures were elucidated by spectral data of IR,MS and NMR.In the preliminary bioassay,compound 1 showed cytotoxicity towards Hep2 and HepG2 with IC₅₀ values of 16 μmol/L and 23 μmol/L,respectively.
- mangrove endophytic fungus,
- ZZF60,
- metabolites,
- anthraquinone,
- antitumor activity
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