Citation: Ying ZHOU, Sai-Nan LIU, Li-Han CAI, Jian-Fu ZHANG, Mao-Lin PANG. Ion-doped Poly(2-nitro-1, 4-phenylenediamine) Nanospheres for Synergistic Photo- and Chemo-Dynamic Therapy[J]. Chinese Journal of Applied Chemistry, ;2021, 38(2): 181-187. doi: 10.19894/j.issn.1000-0518.200266 shu

Ion-doped Poly(2-nitro-1, 4-phenylenediamine) Nanospheres for Synergistic Photo- and Chemo-Dynamic Therapy

Ying ZHOU ¹ ,
Sai-Nan LIU ^{2, 3} ,
Li-Han CAI ^{2, 3} ,
Jian-Fu ZHANG ^1,, ,
Mao-Lin PANG ^{2, 3,,}

1.
School of Chemistry and Environmental Engineering, Changchun University of Science and Technology, Changchun 130022, China
2.
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
3.
University of Science and Technology of China, Hefei 230026, China

Corresponding author: Jian-Fu ZHANG, zhangjianfu@cust.edu.cn Mao-Lin PANG, mlpang@ciac.ac.cn
Received Date: 31 August 2020
Accepted Date: 4 November 2020

Fund Project: the National Natural Science Foundation of China 21471145the Science and Technology Development Planning Project of Jilin Province 20170101179JC

Figures(4)

The complexity of the tumor microenvironment (TME) makes it difficult to completely eliminate tumors with a single treatment. Herein, ion-doped poly(2-nitro-1, 4-phenylenediamine) multifunctional nanospheres loaded with indocyanine green (ICG) are constructed for synergistic cancer therapy by photothermal therapy (PTT)/photodynamic therapy (PDT)/chemo-dynamic therapy (CDT). Under 808 nm laser irradiation, ICG as a photosensitizer could generate ¹O₂ and Fe-PNPD acts as a photothermal agent with a photothermal conversion efficiency of 36.65%. Once Fe-PNPD-ICG (FPIs) is internalized into the cancer cells, it triggers the Fenton reaction to produce ·OH, and clears the over-expressed glutathione (GSH) in TME, thereby reducing the antioxidant capacity in the tumor. At the same time, the generated oxygen can reduce hypoxia in TME and enhance the therapeutic effect of PDT. FPIs is an ideal candidate for synergistic PTT/PDT/CDT therapy, and has broad application prospects for tumor therapy.
- Polynitro-1, 4-phenylenediamine,
- Photothermal therapy,
- Photodynamic therapy,
- Chemo-dynamic therapy
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