基于金属有机框架的纳米酶及其在生物分析中的应用

引用本文: 马逍, 赵丹, 吴培成, 林继泓, 王芳, 许艳杰, 何龙龙, 刘欣雨, 孙健. 基于金属有机框架的纳米酶及其在生物分析中的应用[J]. 分析化学, 2023, 51(6): 922-933. doi: 10.19756/j.issn.0253-3820.221625 shu

Citation: MA Xiao, ZHAO Dan, WU Pei-Cheng, LIN Ji-Hong, WANG Fang, XU Yan-Jie, HE Long-Long, LIU Xin-Yu, SUN Jian. Metal-Organic Framework-based Nanozymes and Their Applications in Bioanalysis[J]. Chinese Journal of Analytical Chemistry, 2023, 51(6): 922-933. doi: 10.19756/j.issn.0253-3820.221625 shu

基于金属有机框架的纳米酶及其在生物分析中的应用

马逍 ^1, ,
赵丹 ^{1,
,} ,
吴培成 ^1, ,
林继泓 ^1, ,
王芳 ^1, ,
许艳杰 ^1, ,
何龙龙 ^1, ,
刘欣雨 ^2, ,
孙健 ^,

1.
洛阳理工学院环境工程与化学学院, 洛阳 471023;
2.
中国科学院长春应用化学研究所, 电分析化学国家重点实验室, 长春 130022

通讯作者: 赵丹,E-mail:lzdzhaodan@163.com; 孙健,E-mail:jiansun@ciac.ac.cn

基金项目:
河南省科技计划项目-科技攻关项目(No.212102210122)、国家自然科学基金项目(No.22104046)、河南省教育厅重点项目(Nos.23A150056,23A530007)和洛阳理工学院高层次人才启动项目(No.2019BZ18)资助。

摘要: 纳米酶是一类具有类酶活性的纳米材料，在分析化学和疾病诊疗领域具有良好的发展潜力。金属有机框架（MOFs）材料是由金属节点和有机配体形成的多孔晶体材料，其结构与天然酶有一定的相似性。目前，研究者已经开发了多种基于MOFs的纳米酶，包括具有类过氧化物酶、类氧化酶、类超氧化物歧化酶和类水解酶活性的纳米酶等，并显示出广阔的应用前景。本文根据材料的结构特点，将基于MOFs的纳米酶分为原始MOFs、化学修饰MOFs、MOFs复合材料和MOFs衍生物4类，介绍了这4类纳米酶制备的基本原理与最新研究进展。在此基础上，根据比色传感、荧光传感和电化学传感等分析策略，综述了MOFs基纳米酶在生物分析方面的研究和应用进展，讨论了其在实际应用中所面临的挑战和未来的发展趋势。

关键词:

English

Metal-Organic Framework-based Nanozymes and Their Applications in Bioanalysis

1.
Department of Environmental Engineering and Chemistry, Luoyang Institute of Science and Technology, Luoyang 471023, China;
2.
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

Corresponding author: ZHAO Dan, ; SUN Jian,

Received Date: 18 December 2022
Revised Date: 15 February 2023
Fund Project:
Supported by the Henan Provincial Science and Technology Plan Project-Science and Technology Research Project (No. 212102210122), the National Natural Science Foundation of China (Nos. 22104046), the Henan Provincial Department of Education Key Project (Nos. 23A150056, 23A530007) and the Luoyang Institute of Science and Technology High-level Talents Startup Project (No. 2019BZ18).

Abstract: Nanozymes, as a class of nanomaterials with enzyme-like activity, exhibit good development and application potential in the fields of analytical chemistry and disease diagnosis and treatment. Metal-organic frameworks (MOFs) materials are porous crystalline materials formed by metal nodes and organic ligands, and their structures have certain similarities with natural enzymes. At present, researchers have developed a variety of nanozymes based on MOFs, including nanozymes with peroxidase-like, oxidase-like, superoxide dismutase-like, and hydrolase-like activities, showing broad application prospects. In this paper, according to the structural characteristics of the materials, MOFs-based nanozymes were divided into four categories, including original MOFs, chemically modified MOFs, MOFs composite materials and MOFs derivatives, and the basic principles and latest developments in the preparation of these nanozymes were introduced. Based on analytical strategies such as colorimetric sensing, fluorescent sensing and electrochemical sensing, the application progress of MOFs-based nanozymes in bioanalysis was reviewed. The challenges of their practical applications and future development trends were also discussed.

Key words:

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

基于金属有机框架的纳米酶及其在生物分析中的应用

通讯作者: 赵丹,E-mail:lzdzhaodan@163.com; 孙健,E-mail:jiansun@ciac.ac.cn

English

Metal-Organic Framework-based Nanozymes and Their Applications in Bioanalysis

Corresponding author: ZHAO Dan, ; SUN Jian,

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

基于金属有机框架的纳米酶及其在生物分析中的应用

通讯作者: 赵丹,E-mail:lzdzhaodan@163.com; 孙健,E-mail:jiansun@ciac.ac.cn

English

Metal-Organic Framework-based Nanozymes and Their Applications in Bioanalysis

Corresponding author: ZHAO Dan, ; SUN Jian,

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

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通讯作者: 陈斌, bchen63@163.com

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