Citation: SUN Zhi-Yuan, FAN Wen-Fang, WANG Yong, ZHUANG Qian-Fen. Poly(neutral red)/Multi-walled Carbon Nanotube Composite Modified Electrochemical Sensor for Ratiometric Detection of Estriol[J]. Chinese Journal of Analytical Chemistry, ;2023, 51(1): 42-52. doi: 10.19756/j.issn.0253-3820.221543 shu

Poly(neutral red)/Multi-walled Carbon Nanotube Composite Modified Electrochemical Sensor for Ratiometric Detection of Estriol

School of Chemistry and Chemical Engineering, Nanchang University, Nanchang 330031, China

Corresponding author: ZHUANG Qian-Fen, qfzhuang@ncu.edu.cn
Received Date: 3 November 2022
Revised Date: 23 November 2022

Fund Project: Supported by the National Natural Science Foundation of China (Nos.31960495, 32160600, 21864017).

A poly(neutral red)/multi-walled carbon nanotube nanocomposite modified electrochemical sensor was established for ratiometric sensing of estriol. The poly(neutral red) was used as the internal reference electroactive probe, and the oxidation peak current ratio of estriol to poly(neutral red) was used for accurate quantitative detection of estriol. The poly(neutral red)/multi-walled carbon nanotube nanocomposite was demonstrated good electroconductivity and high electrocatalytic performance which could improve the detection sensitivity. The response of the ratiometric sensor was linearly proportion to the estriol concentration in the 0.1-2.0 μmol/L range, with a limit of detection (S/N=3) of 0.08 μmol/L. The electrochemical oxidation reaction of estriol on the poly(neutral red)/multiwalled carbon nanotube nanocomposite/glassy carbon electrode was demonstrated to undergo a two-electron/two-proton process. Moreover, the sensor had high sensitivity, strong anti-interference ability and good stability, and was successfully applied to testriol analysis in pharmaceutical cream, urine and lake water samples.
- Estriol,
- Poly(neutral red),
- Ratiometric sensor,
- Electrochemistry
1. [1]
  ESPOSITO G. Gynecol. Endocrinol., 1991, 5(2):131-153.
2. [2]
  HEAD K A. Altern. Med. Rev., 1998, 3(2):101-113.
3. [3]
  HUANG X Z, SPINK D C, SCHNEIGER E, LING H L, RAI A J, ROSANO T G, CHEN B R, CAO Z M. Clin. Chem., 2014, 60(1):260-268.
4. [4]
  LEIS H J, FAULER G, RECHBERGER G N, WINDISCHHOFER W. J. Chromatogr. B:Anal. Technol. Biomed. Life Sci., 2003, 794(2):205-213.
5. [5]
  TANG Y P, ZHAO S Q, WU Y S, ZHOU J W, LI M. Anal. Methods., 2013, 5(16):4068-4073.
6. [6]
  BARRETO F C, SILVA M K L, CESARINO I. Chemosensors, 2022, 10(10):395.
7. [7]
  CHARITHRA M M, MANJUNATHA J G G, RARIL C. Adv. Pharm. Bull., 2020, 10(2):247-253.
8. [8]
  JODAR L V, SANTOS F A, ZUCOLOTTO V. J. Solid State Electrochem., 2018, 22(5):1431-1438.
9. [9]
  SILVEIRA J, PIOVESAN J V, SPINELLI A. Microchem. J., 2017, 133:22-30.
10. [10]
  ZHAO Q, FARAJ Y, LIU L Y, WANG W, XIE R, LIU Z, JU X J, WEI J, CHU L Y. Microchem. J., 2020, 158:105185.
11. [11]
  RAYMUNDO-PEREIRA P A, CAMPOS A M, VICENTINI F C, JANEGITZ B C, MENDONCA C D, FURINI L N, BOAS N V, CALEGARO M L, CONSTANTINO C J L, MACHADO S A S, OLIVEIRA O N. Talanta, 2017, 174:652-659.
12. [12]
  JIN H, GUI R J, YU J B, LV W, WANG Z H. Biosens. Bioelectron., 2017, 91:523-537.
13. [13]
  KARYAKIN A A, BOBROVA O A, KARYAKINA E E. J. Electroanal. Chem., 1995, 399(1-2):179-184.
14. [14]
  YANG Y X, YANG J, HE Y C, LI Y C. Sens. Actuators, B, 2021, 330(7):129302.
15. [15]
  SLJUKIC B, BANKS C E, COMPTON R G. Nano Lett., 2006, 6(7):1556-1558.
16. [16]
  XIANG L, ZHANG Z N, YU P, ZHANG J, SU L, OHSAKA T, MAO L Q. Anal. Chem., 2008, 80(17):6587-6593.
17. [17]
  BARD A J, FAULKNER L R. Electrochemical Methods:Fundamentals and Applications, 2nd Ed. New York:John Wiley and Sons., 2001.
18. [18]
  MAYER P, HOLZE R. Surf. Sci., 2003, 522(1-3):55-63.
19. [19]
  MORAVKOVA Z, TRCHOVA M, TOMSIK E, CECHVALA J, STEJSKAL J. Polym. Degrad. Stab., 2012, 97(8):1405-1414.
20. [20]
  MAZEIKIENE R, NIAURA G, MALINAUSKAS A. J. Colloid Interface Sci., 2009, 336(1) 195-199.
21. [21]
  LAVIRON E. J. Electroanal. Chem. Interfacial Electrochem., 1979, 101(1):19-28.
22. [22]
  MING Y C, LONG Y J, JUN T X, ZHEN Z G, YUE Z. React. Funct. Polym., 2006, 66(11):1336-1341.
1. [1]
  Zihan Lin , Wanzhen Lin , Fa-Jie Chen . Electrochemical Modifications of Native Peptides. University Chemistry, 2025, 40(3): 318-327. doi: 10.12461/PKU.DXHX202406089
2. [2]
  Yongming Zhu , Huili Hu , Yuanchun Yu , Xudong Li , Peng Gao . Construction and Practice on New Form Stereoscopic Textbook of Electrochemistry for Energy Storage Science and Engineering: Taking Basic Course of Electrochemistry as an Example. University Chemistry, 2024, 39(8): 44-47. doi: 10.3866/PKU.DXHX202312086
3. [3]
  Cen Zhou , Biqiong Hong , Yiting Chen . Application of Electrochemical Techniques in Supramolecular Chemistry. University Chemistry, 2025, 40(3): 308-317. doi: 10.12461/PKU.DXHX202406086
4. [4]
  Yongjian Zhang , Fangling Gao , Hong Yan , Keyin Ye . Electrochemical Transformation of Organosulfur Compounds. University Chemistry, 2025, 40(5): 311-317. doi: 10.12461/PKU.DXHX202407035
5. [5]
  Linbao Zhang , Weisi Guo , Shuwen Wang , Ran Song , Ming Li . Electrochemical Oxidation of Sulfides to Sulfoxides. University Chemistry, 2024, 39(11): 204-209. doi: 10.3866/PKU.DXHX202401009
6. [6]
  Shuhui Li , Rongxiuyuan Huang , Yingming Pan . Electrochemical Synthesis of 2,5-Diphenyl-1,3,4-Oxadiazole: A Recommended Comprehensive Organic Chemistry Experiment. University Chemistry, 2025, 40(5): 357-365. doi: 10.12461/PKU.DXHX202407028
7. [7]
  Hongyi LI , Aimin WU , Liuyang ZHAO , Xinpeng LIU , Fengqin CHEN , Aikui LI , Hao HUANG . Effect of Y(PO₃)₃ double-coating modification on the electrochemical properties of Li[Ni_0.8Co_0.15Al_0.05]O₂. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1320-1328. doi: 10.11862/CJIC.20230480
8. [8]
  Jianfeng Yan , Yating Xiao , Xin Zuo , Caixia Lin , Yaofeng Yuan . Comprehensive Chemistry Experimental Design of Ferrocenylphenyl Derivatives. University Chemistry, 2024, 39(4): 329-337. doi: 10.3866/PKU.DXHX202310005
9. [9]
  Yifei Cheng , Jiahui Yang , Wei Shao , Wanqun Zhang , Wanqun Hu , Weiwei Li , Kaiping Yang . Learning Goes Beyond the Written Word: Practical Insights from the “Leaf Electroplating” Popular Science Experiment. University Chemistry, 2024, 39(9): 319-327. doi: 10.3866/PKU.DXHX202310033
10. [10]
  Kuaibing Wang , Honglin Zhang , Wenjie Lu , Weihua Zhang . Experimental Design and Practice for Recycling and Nickel Content Detection from Waste Nickel-Metal Hydride Batteries. University Chemistry, 2024, 39(11): 335-341. doi: 10.12461/PKU.DXHX202403084
11. [11]
  Bing WEI , Jianfan ZHANG , Zhe CHEN . Research progress in fine tuning of bimetallic nanocatalysts for electrocatalytic carbon dioxide reduction. Chinese Journal of Inorganic Chemistry, 2025, 41(3): 425-439. doi: 10.11862/CJIC.20240201
12. [12]
  Kuaibing Wang , Feifei Mao , Weihua Zhang , Bo Lv . Design and Practice of a Comprehensive Teaching Experiment for Preparing Biomass Carbon Dots from Rice Husk. University Chemistry, 2025, 40(5): 342-350. doi: 10.12461/PKU.DXHX202407042
13. [13]
  Zeqiu Chen , Limiao Cai , Jie Guan , Zhanyang Li , Hao Wang , Yaoguang Guo , Xingtao Xu , Likun Pan . Advanced electrode materials in capacitive deionization for efficient lithium extraction. Acta Physico-Chimica Sinica, 2025, 41(8): 100089-0. doi: 10.1016/j.actphy.2025.100089
14. [14]
  Jiarong Feng , Yejie Duan , Chu Chu , Dezhen Xie , Qiu'e Cao , Peng Liu . Preparation and Application of a Streptomycin Molecularly Imprinted Electrochemical Sensor: A Suggested Comprehensive Analytical Chemical Experiment. University Chemistry, 2024, 39(8): 295-305. doi: 10.3866/PKU.DXHX202401016
15. [15]
  Meiqing Yang , Lu Wang , Haozi Lu , Yaocheng Yang , Song Liu . Recent Advances of Functional Nanomaterials for Screen-Printed Photoelectrochemical Biosensors. Acta Physico-Chimica Sinica, 2025, 41(2): 100018-. doi: 10.3866/PKU.WHXB202310046
16. [16]
  Huirong BAO , Jun YANG , Xiaomiao FENG . Preparation and electrochemical properties of NiCoP/polypyrrole/carbon cloth by electrodeposition. Chinese Journal of Inorganic Chemistry, 2025, 41(6): 1083-1093. doi: 10.11862/CJIC.20250008
17. [17]
  Tiantian MA , Sumei LI , Chengyu ZHANG , Lu XU , Yiyan BAI , Yunlong FU , Wenjuan JI , Haiying YANG . Methyl-functionalized Cd-based metal-organic framework for highly sensitive electrochemical sensing of dopamine. Chinese Journal of Inorganic Chemistry, 2024, 40(4): 725-735. doi: 10.11862/CJIC.20230351
18. [18]
  Xingchao Zhao , Xiaoming Li , Ming Liu , Zijin Zhao , Kaixuan Yang , Pengtian Liu , Haolan Zhang , Jintai Li , Xiaoling Ma , Qi Yao , Yanming Sun , Fujun Zhang . 倍增型全聚合物光电探测器及其在光电容积描记传感器上的应用. Acta Physico-Chimica Sinica, 2025, 41(1): 2311021-. doi: 10.3866/PKU.WHXB202311021
19. [19]
  Lu XU , Chengyu ZHANG , Wenjuan JI , Haiying YANG , Yunlong FU . Zinc metal-organic framework with high-density free carboxyl oxygen functionalized pore walls for targeted electrochemical sensing of paracetamol. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 907-918. doi: 10.11862/CJIC.20230431
20. [20]
  Jing SU , Bingrong LI , Yiyan BAI , Wenjuan JI , Haiying YANG , Zhefeng Fan . Highly sensitive electrochemical dopamine sensor based on a highly stable In-based metal-organic framework with amino-enriched pores. Chinese Journal of Inorganic Chemistry, 2024, 40(7): 1337-1346. doi: 10.11862/CJIC.20230414

Get Citation

PDF

XML

Metrics

PDF Downloads(7)
Abstract views(733)
HTML views(56)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142