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基于曼尼希反应的聚集诱导发光效应用于灵敏检测甲醛

吴金丹 ,  曹莹姿 ,  陈凯欣 ,  查勇超 ,  刘鸿燊 ,  周平 ,  李楠

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引用本文: 吴金丹, 曹莹姿, 陈凯欣, 查勇超, 刘鸿燊, 周平, 李楠. 基于曼尼希反应的聚集诱导发光效应用于灵敏检测甲醛[J]. 分析化学, 2023, 51(2): 194-203. doi: 10.19756/j.issn.0253-3820.221482 shu
Citation:  WU Jin-Dan,  CAO Ying-Zi,  CHEN Kai-Xin,  ZHA Yong-Chao,  LIU Hong-Shen,  ZHOU Ping,  LI Nan. Mannich Reaction Based Aggregation-induced Emission for Fluorescent Sensitive Detection of Formaldehyde[J]. Chinese Journal of Analytical Chemistry, 2023, 51(2): 194-203. doi: 10.19756/j.issn.0253-3820.221482 shu

基于曼尼希反应的聚集诱导发光效应用于灵敏检测甲醛

  • 暨南大学生命科学技术学院生物医学工程系, 生物材料广东高校重点实验室, 广州 510632

    • 通讯作者: 李楠,E-mail:linanbie@jnu.edu.cn
  • 基金项目:

    广东省基础与应用基础研究基金项目(No.2020A1515010957)资助。

摘要: 甲醛是一类无色无味的致癌物，严重危害人类健康，对甲醛的灵敏检测在环境监测、毒物评估、临床诊断和医疗保健等领域均具有非常重要的意义。本研究合成了具有聚集诱导发光（Aggregation-inducedemission，AIE）效应的荧光探针四羟基四苯基乙烯（Tetra（4-hydroxyphenyl）ethylene，TPE-4OH），在1,2,4,5-苯四胺四盐酸盐（1,2,4,5-Benzenetetramine tetrahydrochloride，BTA）存在条件下，TPE-4OH与溶液中的甲醛分子发生曼尼希反应，从而发生AIE，引起荧光增强，荧光强度变化与体系中的甲醛水平密切相关，通过测定TPE-4OH的AIE强度可检测水溶液中甲醛浓度。优化了反应物浓度、溶液pH值以及反应时间等条件。在最优条件下，本方法检测甲醛的线性范围为1.0~2000 μmol/L，检出限为1.0 μmol/L。将本方法应用于血清样品中甲醛浓度的检测，回收率为93.7%~106.4%，显示了良好的实际应用价值，为水溶液中甲醛浓度检测提供了一种新方法。

English


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  • 收稿日期:  2022-09-28
  • 修回日期:  2022-11-23
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