Citation: CAO Qing, LI Dong, JIANG Yan-Xia, QI Ke-Zhen, ZHANG Man-Jie. Fabrication of Unique Polydopamine/Poly(acrylic acid)-Copper Hydroxide Janus Nanoparticles for Photoacoustic Imaging and Chemo-Photothermal Cancer Therapy in Vitro[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(8): 1205-1216. doi: 10.19756/j.issn.0253-3820.221122 shu

Fabrication of Unique Polydopamine/Poly(acrylic acid)-Copper Hydroxide Janus Nanoparticles for Photoacoustic Imaging and Chemo-Photothermal Cancer Therapy in Vitro

CAO Qing ¹ ,
LI Dong ¹ ,
JIANG Yan-Xia ¹ ,
QI Ke-Zhen ^2,, ,
ZHANG Man-Jie ^1,,

1.
Institute of Catalysis for Energy and Environment, College of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang 110034, China;
2.
Institute of Pharmacy, Dali University, Dali 671000, China

Corresponding author: QI Ke-Zhen, ZHANG Man-Jie,
Received Date: 11 March 2022
Revised Date: 27 April 2022

Fund Project: Supported by the National Natural Science Foundation of China (No.22002096), the Natural Science Foundation of Liaoning Province, China (No.2019BS219) and the Liaoning Revitalization Talents Program (No.XLYC1807238).

The polydopamine/poly(acrylic acid)-copper hydroxide Janus nanoparticles (PDA/PAA-Cu(OH)₂ JNPs) were prepared by a novel and simple method. PDA had a strong absorption in the near infrared (NIR) region, with excellent biocompatibility and degradation, and the PAA-Cu(OH)₂ was formed via coordination between the carboxyl groups of PAA and copper ions (Cu²⁺) by introducing Cu(NO₃)₂, which was used for loading anticancer drug. The PAA-Cu(OH)₂ domains also had strong absorption in the NIR region for photothermal therapy, realizing the organic fusion of different functions and showing synergistic effect. The hydrophilic doxorubicin (DOX) was chosen as drug model for exposing the inhibition efficiency of the HepG-2 cells. The obtained JNPs had high drug-loading contents (0.87 mg/mg, DOX/JNPs), good photothermal conversion efficiency (45.9%), pH/NIR bimodal-triggered controlled drug release ability and photoacoustic (PA) imaging capacity, enabling the JNPs to be applied to PA imaging and synergistic cancer chemo-phototherapy in vitro. The cytotoxicity assay in vitro proved that the group treated with DOX-loaded PDA/PAA-Cu(OH)₂ JNPs plus laser showed distinct cell death, and the viability of the cells were exceedingly low (7.9%).
- Janus nanoparticles,
- Polydopamine,
- Dual-responsive drug release,
- Photoacoustic imaging,
- Chemo-photothermal therapy
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