Citation: YU Qiong-Lin, LIANG Ping, JIAN Wei, QIAO Ting-Yi, DONG Nan. Column-free Matrix Solid Phase Dispersion Extraction Based on Cucurbit[7]uril Coupled with High Performance Liquid Chromatography for Determination of Camptothecin Content in Camptotheca acuminate Decne[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(8): 1217-1223. doi: 10.19756/j.issn.0253-3820.221066 shu

Column-free Matrix Solid Phase Dispersion Extraction Based on Cucurbit[7]uril Coupled with High Performance Liquid Chromatography for Determination of Camptothecin Content in Camptotheca acuminate Decne

YU Qiong-Lin ¹ ,
LIANG Ping ¹ ,
JIAN Wei ¹ ,
QIAO Ting-Yi ¹ ,
DONG Nan ^1,2,,

1.
School of Chemistry and Chemical Engineering, Guizhou University, Guiyang 550025, China;
2.
Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Guiyang 550025, China

Corresponding author: DONG Nan, ndong@gzu.edu.cn
Received Date: 9 February 2022
Revised Date: 26 May 2022

Fund Project: Supported by the Guizhou Science and Technology Foundation (No.ZK[2021] General 054) and the National Natural Science Foundation of China (No.22164006).

A simple, rapid and environmentally friendly method named column-free matrix solid-phase dispersion (FMSPD) was developed for extraction of camptothecin from the fruits of Camptotheca acuminate Decne. Cucurbit[7]uril (Q[7]) was used as the sorbent of FMSPD to selectively extract camptothecin, which was transferred into an aqueous solution and was directly detected using high performance liquid chromatography-ultraviolet detector (HPLC-UV) based on the recognition interaction of Q[7] toward the compound. The factors that influenced the extraction efficiency were investigated, including the amount of Q[7], grinding time, volume of added water, and pH value of the solution. Under the optimal experimental conditions, the dynamic linear range of the developed FMSPD-HPLC-UC method was 1.0-100 μg/mL, the limit of detection was 0.15 μg/mL, and the intra- and inter-day precisions were 4.5% and 5.2%, respectively. The mean recoveries (n=3) at three spiked concentration levels were from 97.1% to 119.3%. The developed method was applied to analyze four kinds of fruits of Camptotheca acuminate Decne.F- and t-tests showed that the results had no significant difference when comparing the traditional ultrasound-assisted extraction method to the novel FMSPD extraction method. However the method developed here was simpler, faster and did not use organic solvents.
- Cucurbit[7]uril,
- Matrix solid phase dispersion,
- Camptothecin,
- Fruits of Camptotheca acuminate Decne
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