Citation: GUO Shang, CHEN Guang-Shi, ZHOU Jing, LIANG Wen-Yao, TAN Jian-Hua, PENG Xian-Zhi. Non-target Screening of Plastic Additives Leaching under Artificial Biodigestive Condition Using Ultra-High Performance Liquid Chromatography Coupled with Quadrupole-Orbitrap Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(9): 1373-1383. doi: 10.19756/j.issn.0253-3820.221053 shu

Non-target Screening of Plastic Additives Leaching under Artificial Biodigestive Condition Using Ultra-High Performance Liquid Chromatography Coupled with Quadrupole-Orbitrap Mass Spectrometry

GUO Shang ^1,2 ,
CHEN Guang-Shi ^1,2 ,
ZHOU Jing ^1,2 ,
LIANG Wen-Yao ⁴ ,
TAN Jian-Hua ⁴ ,
PENG Xian-Zhi ^1,3,,

1.
Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510603, China;
2.
University of Chinese Academy of Sciences, Beijing 100049, China;
3.
CAS Center for Excellence in Deep Earth Science, Chinese Academy of Sciences, Guangzhou 510603, China;
4.
Guangzhou Quality Supervision and Testing Institute, Guangzhou 511447, China

Corresponding author: PENG Xian-Zhi, pengx@gig.ac.cn
Received Date: 26 January 2022
Revised Date: 16 June 2022

Fund Project: Supported by the National Natural Science Foundation of China (Nos.4207070014, 41877365).

A non-target screening method based on ultra-high performance liquid chromatography-quadrupole-orbitrap high resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS) was established for screening and identification of plastic additives in plastic products. Chromatographic separation was performed on a Hypersil GOLD C₁₈ chromatographic column. The MS data were obtained under MS/dd-MS² scan mode with electrospray ionization source (HESI) in both positive and negative ion modes. A MS data base including 31 kinds of plastic additives and a suspect list including more than 6028 kinds of plastic additives were established. The non-target screen workflow including UHPLC-HRMS method, MS data analysis and compound identification were optimized. According to the matching level of precursor ion (MS), fragment ions (MS2) and retention time (RT) with data bases and/or silico fragment, the compounds screened here could be categorized based on confidence levels from L1 to L4. A total of 1944 compounds in the extract of PVC sheath of cords were screened and identified by the developed non-target screening method, among which 4 compounds including diethyl phthalate (DEP), bis(2-ethylhexyl) phthalate (DEHP), tris(2-chloroethyl) phosphate (TCEP) and bisphenol A (BPA) were identified as L1 confidence, 88 and 50 compounds were identified as L2 and L3 confidence (phthalates, amides, alkenoic acids, etc.). This method was further applied to primary investigation of plastic additives released from typical plastic products under the artificial biodigestive system. A total of 132 kinds of additives were identified. L1 compounds included DEHP, BPA, drometrizole (UVP) and triethyl phosphate (TEP), with release amount of 4.6 mg/g, 38.1 μg/g, 47.8 ng/g and 158.2 ng/g, respectively.
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