Citation: CAI Le-Si, HUO Yu-Meng, TIAN Wei, ZHAO Xia, ZHANG Si-Chun, ZHANG Xin-Rong. Application of Matrix-assisted Laser Desorption Ionization Mass Spectrometry Imaging Technique in Illicit Drug Research[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(7): 973-984. doi: 10.19756/j.issn.0253-3820.221037 shu

Application of Matrix-assisted Laser Desorption Ionization Mass Spectrometry Imaging Technique in Illicit Drug Research

CAI Le-Si ^1,2 ,
HUO Yu-Meng ¹ ,
TIAN Wei ¹ ,
ZHAO Xia ^1,, ,
ZHANG Si-Chun ² ,
ZHANG Xin-Rong ²

1.
Beijing Narcotics Control Technology Center, Beijing 100164, China;
2.
Department of Chemistry, Tsinghua University, Beijing 100084, China

Corresponding author: ZHAO Xia, lubin_fast@sohu.com
Received Date: 19 January 2022
Revised Date: 18 March 2022

Fund Project: Supported by the Narcotics Control Technology Project of the Ministry of Public Security of the People's Republic of China (No.2021jdgga06).

At present, the drug situation at home and abroad is still severe. The development of new drugs is extremely fast, the levels of concealment and complexity of drug-related cases are increasing, and the mechanism of drug addiction is still unclear. Therefore, it is urgent to develop advanced drug analytical methods to deal with the above international problems. Mass spectrometry imaging technology has both molecular identification and imaging functions, providing a new analytical method and research horizon for drug research. Matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI), as a typical representative of mass spectrometry imaging technology, has been widely used in drug-related basic scientific research and detection method development. In this paper, the applications of MALDI-MSI in drug addiction mechanism, forensic drug analysis and drug original plant research were reviewed. The future directions and applications of this technology in the drug-related research were also discussed.
- Matrix-assisted laser desorption ionization mass spectrometry,
- Illicit drug,
- Chemical imaging,
- Review
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沈阳化工大学材料科学与工程学院沈阳 110142