Citation: LUO Da, ZHANG Yi, YANG Xiao-Wen, CHENG Fang-Fang, ZHANG Li. Application of Up-conversion Nanomaterials in Detection of MicroRNAs[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(9): 1428-1436. doi: 10.19756/j.issn.0253-3820.211186 shu

Application of Up-conversion Nanomaterials in Detection of MicroRNAs

Jiangsu Provincial Collaborative Innovation Center for Industrialization Process of Traditional Chinese Medicine Resources/National-Local Joint Engineering Research Center for Traditional Chinese Medicine Resources Industrialization, Prescriptions and Innovative Drugs, Nanjing University of Chinese Medicine, Nanjing 210023, China

Corresponding author: CHENG Fang-Fang, ZHANG Li,
Received Date: 15 March 2021
Revised Date: 6 June 2021

Fund Project: Supported by the National Natural Science Foundation of China (No.21705081), the Natural Science Foundation of Jiangsu Province, China (Nos.BK20161037, BK20201232) and the 333 High-level Talents Training Project Funded by Jiangsu Province, China (No.BRA2020071).

The occurrence and development of diseases are often accompanied by abnormal expression of certain microRNAs. MicroRNAs are small and non-coding RNA molecules which play an important role in many basic physiological and pathological processes as post-transcriptional regulators of gene expression. At present, many studies have shown that microRNAs can be used as biomarkers for diagnosis and treatment of diseases. Traditional detection methods of microRNAs often have shortcomings such as low sensitivity and poor selectivity, and cannot achieve real-time detection. Rare earth upconversion nanomaterials have unique anti-stokes shift properties and advantages including good photobleaching resistance, low tissue autofluorescence interference, good biocompatibility and low toxicity, and thus are commonly used for microRNAs detection. Therefore, detecting the changes of expression level of microRNAs using up-conversion nanomaterials in real-time can identify the occurrence and development of diseases, and provide evidence for the diagnosis, treatment and prognosis of diseases. In this papar, the application progress of up-conversion nanomaterials in detection of microRNAs in recent years is reviewed.
- Rare earth up-conversion nanomaterials,
- MicroRNAs,
- Photoluminescence,
- Fluorescence resonance energy transfer,
- Ratiometric fluorescence,
- Review
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