Citation: WANG Ling-Yuan, WANG Hao-Wei, LU Si-Min, LONG Yi-Tao. Single-entity Measurement Based on Electro-optical Confinement of Nanopores[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(7): 1166-1175. doi: 10.19756/j.issn.0253-3820.211041 shu

Single-entity Measurement Based on Electro-optical Confinement of Nanopores

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China

Corresponding author: LU Si-Min, LONG Yi-Tao,
Received Date: 18 January 2021
Revised Date: 22 March 2021

Fund Project: Supported by the National Training Program of Innovational for Undergraduates (No. 202010284101Z).

Nanopores technique is a label-free, high-throughput, high-spatial-temporal resolution electrochemical measurement method for single-molecule level analysis, which is widely used for single-entity measurements such as single molecules, single particles, and single cells. Nanopores not only have adjustable three-dimensional space to confine single analytes, but also possess an ability to enhance the electrical and magnetic fields. In short, the nanopores exhibit unique sub-wavelength optical properties. In this review, we introduce the principle of nanopore electrochemical analysis, and give a perspective and detailed overview of its application in electro-optical binding measurements.
- Nanopore,
- Single-entity measurements,
- Confined effect,
- Electro-optical measurements,
- Review
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