Citation: CHEN Xiu-Ying, GAO Bao-Xiang, ZHOU Huan-Ying. Recent Progress in Matrix for Analysis of Low Molecular Weight Compounds Using Matrix Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(1): 12-24. doi: 10.19756/j.issn.0253-3820.211012 shu

Recent Progress in Matrix for Analysis of Low Molecular Weight Compounds Using Matrix Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry

1.
Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China;
2.
Institute of Environmental and Operational Medicine, Academy of Military Medical Science, Academy of Military Science, Tianjin 300050, China

Corresponding author: GAO Bao-Xiang, ZHOU Huan-Ying,
Received Date: 6 January 2021
Revised Date: 22 October 2021

Fund Project: Supported by the National Key Research and Development Program of China (No.2017YFF0211301).

Matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOFMS) is a soft ionization mass spectrometry technology and widely used in the analysis of various molecules such as proteins, polypeptides, nucleic acids and polymers, etc. However, the application of MALDI-TOF MS on detection of low molecular weight compounds (LMWC) is limited due to the matrix related peak interference and inhomogeneous crystallization of matrix/analyte. In recent years, a variety of novel matrixes have been developed for detection of LMWC. This paper reviews the matrix of MALDI-TOF MS in recent 10 years from three aspects, including new inorganic material matrix, organic compound matrix and other matrix (metal organic framework, ionic liquid matrix, reactive matrix, etc.) The research progress of determination of LMWC by MALDI-TOF MS, and the preparation, characteristics and application of matrix are introduced, and the future development trend is prospected.
- Matrix assisted laser desorption ionization time-of-flight mass spectrometry,
- Matrix,
- Low molecular weight compounds,
- Review
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