Citation: LI Yang, LI Qing-Yun, XU Chu-Ting, RUAN Hui-Wen, ZHAO Kun, HUA Lei, LI Hai-Yang. Research Progress of Lung Cancer Screening Technology Based on Detection of Exhaled Volatile Organic Compounds[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(2): 183-197. doi: 10.19756/j.issn.0253-3820.210617 shu

Research Progress of Lung Cancer Screening Technology Based on Detection of Exhaled Volatile Organic Compounds

LI Yang ^1,2,3 ,
LI Qing-Yun ^1,2,3,4 ,
XU Chu-Ting ^1,2,3 ,
RUAN Hui-Wen ^1,2,3 ,
ZHAO Kun ^1,2,3 ,
HUA Lei ^1,2,3,, ,
LI Hai-Yang ^1,2,3,,

1.
CAS Key Laboratory of Separation and Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China;
2.
Dalian Engineering Research Center of Breath Diagnostic Technology, Dalian 116023, China;
3.
Dalian Key Laboratory for Online Analytical Instrumentation, Dalian 116023, China;
4.
PCAB Research Center of Breath and Metabolism, Beijing 100074, China

Corresponding author: HUA Lei, LI Hai-Yang,
Received Date: 9 July 2021
Revised Date: 9 November 2021

Fund Project: Supported by the National Natural Science Foundation of China (No.22027804), the Liaoning Revitalization Talents Program (No.XLYC1808022) and the Dalian High-Level Talents Innovation Support Project (No.2019RQ101)

Lung cancer has the highest morbidity and mortality among malignant tumors worldwide. The cure rate of lung cancer is high for early diagnosis, thus “early diagnosis and early treatment” has become a consensus. Exhaled gas detection has many advantages including non-invasive detection, convenient sampling and friendly to human body. The biomarkers for early lung cancer might be found through measurement of characteristic metabolites in exhaled gas. Therefore, it is expected to be a simple and effective method of early lung cancer screening, which has attracted lots of attentions. This review summarizes the research progress of early lung cancer screening technology based on detection of exhaled volatile organic compounds (VOCs), including the common clinical screening methods for lung cancer, the exhaled gas components and characteristic VOCs of lung cancer, the collection and pretreatment methods for exhaled VOCs, and the detection techniques for characteristic VOCs of lung cancer. The problems of exhaled gas detection in early lung cancer screening and their future research orientations are also discussed.
- Exhaled gas,
- Volatile organic compounds,
- Lung cancer,
- Early screening,
- Review
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