Citation: LI Shi-Cheng, LI Ming-Hui, CHEN Zi-Long, ZHU Xin-Hai. Analysis of Nonpolar Polymers by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(1): 82-91. doi: 10.19756/j.issn.0253-3820.210593 shu

Analysis of Nonpolar Polymers by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

1.
School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou 510006, China;
2.
School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China;
3.
Instrumental Analysis & Research Center, Sun Yat-sen University, Guangzhou 510275, China

Corresponding author: ZHU Xin-Hai, zhuxinh@mail.sysu.edu.cn
Received Date: 28 June 2021
Revised Date: 18 November 2021

The influence of ionization reagent on the determination results of non-polar polymers by matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS) was investigated. As a comparison, trans-2-[3-(4-tert-butylphenyl)-2-methyl-propylene] malononitrile (DCTB) was selected as the matrix, and polybutadiene 5000 (PB5000), polystyrene (PS) with different degree of polymerization and polyethylene 2000 (PE2000) were selected as the samples.The ionization of nine copper salts was investigated. The results showed that, under the same test conditions, copper nitrate could be used as an ionization reagent for the analysis of three kinds of non-polar polymers with the best signal intensity and resolution of the polymer spectra.In the analysis of PB5000, further cold-field scanning electron microscopy (SEM) analysis showed that copper nitrate mixed with PB5000 and DCTB could obtain more uniform crystallization in comparison with other copper salts.Using DCTC as the matrix and copper nitrate as the cation reagent, thin layer chromatography-matrix-assisted laser desorption ionization time of flight mass spectrometry (TLC-MALDI-TOF MS) coupling technology couldeffectively reduce or eliminate the influence of ion inhibition caused by dopants such as small molecule salt (sodium iodide) and other polymers (polyethylene glycol) which were easy to ionize in the analysis of polyolefin by MALDI-TOF. The effective analysis of impurity doped polymers PB5000 and PS4000 was realized successfully. This method had many advantages such as fast analysis speed, low cost and simple operation. This study provided an effective solution for MALDI-TOF MS analysis of low purity nonpolar polymers.
- Nonpolar polymers,
- Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry,
- Ionization reagent,
- Copper salt,
- Thin-layer chromatography
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