Citation: ZENG Ying-Jie, ZHI Yu-Liang, FAN Xian-Guang, WANG Xin. Design and Evaluation of Integrated Tip-enhanced Raman Spectrometer[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(1): 39-46. doi: 10.19756/j.issn.0253-3820.210483 shu

Design and Evaluation of Integrated Tip-enhanced Raman Spectrometer

ZENG Ying-Jie ¹ ,
ZHI Yu-Liang ¹ ,
FAN Xian-Guang ^1,2,, ,
WANG Xin ^1,2,,

1.
Department of Instrumental and Electrical Engineering, Xiamen University, Xiamen 361102, China;
2.
Fujian Key Laboratory of Universities and Colleges for Transducer Technology, Xiamen University, Xiamen 361102, China

Corresponding author: FAN Xian-Guang, WANG Xin,
Received Date: 6 May 2021
Revised Date: 8 November 2021

Fund Project: Supported by the National Natural Science Foundation of China (Nos.21974118, 21874113).

Tip-enhanced Raman spectroscopy (TERS) is a new analytical technology that combines Raman spectroscopy and scanning probe microscopies (SPM). By enhancing the Raman signal at "hot spots", it is possible to have a deeper understanding of molecular composition and structure, reaction mechanism, and molecular orientation. At present, most of tip-enhanced Raman instruments adopt a split design, which is bulky, expensive and complicated in structure, limiting the popularization of the instrument and the development of related research. In this work, an integrated tip-enhanced Raman spectroscopy instrument was designed and developed, which effectively improved the integration of the instrument, reduced the transmission loss of the optical fiber and reduced the volume and cost of the system. The spectrometer consisted of a laser excitation and Raman collection module, a spectrometer module, and a tip and laser coupled imaging module. The three modules were placed in a closed housing with a volume of 410 mm×305 mm×85 mm. The instrument was optically calibrated using a standard Ne-Ar light source. The resolution of the instrument was 0.56 nm, and the spectral detection range was 640-770 nm. For the Ne-Ar calibration light source, the observed profile was Gaussian lineshape, and the contour of the ν(A1) vibration peak of carbon tetrachloride was a combination of 51% Gaussian and 49% Lorentzian lines. Finally, the tip-enhanced Raman spectrum of 4'-(pyridine-4-yl)-biphenyl-4-yl) methanethiol (4-PBT) molecules was successfully obtained using this spectrometer, which verified the feasibility of the integrated spectrometer and provided technical accumulation for the promotion of tip Raman spectroscopy technology.
- Tip-enhanced Raman spectroscopy,
- Instrument design,
- Spectrograph calibration,
- Raman spectrum
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