Citation: GUO Xing, ZHAO Zhong-Jun, DAI Jian-Xiong, HE Fei-Yao, LI Hong, WANG Jia-Yu, LIU Wei, WANG Xin, ZHANG Xin-Xue, YANG Yan-Ting, DUAN Yi-Xiang. Development of A Travelling Wave-based Ion Mobility Spectrometer[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(9): 1461-1469. doi: 10.19756/j.issn.0253-3820.210458 shu

Development of A Travelling Wave-based Ion Mobility Spectrometer

GUO Xing ¹ ,
ZHAO Zhong-Jun ² ,
DAI Jian-Xiong ¹ ,
HE Fei-Yao ³ ,
LI Hong ³ ,
WANG Jia-Yu ¹ ,
LIU Wei ⁴ ,
WANG Xin ¹ ,
ZHANG Xin-Xue ¹ ,
YANG Yan-Ting ⁵ ,
DUAN Yi-Xiang ^1,5,,

1.
College of Chemistry & Materials Science, Northwest University, Xi'an 710127, China;
2.
School of Chemical Engineering, Sichuan University, Chengdu 610064, China;
3.
College of Life Sciences, Sichuan University, Chengdu 610064, China;
4.
College of Information Science & Technology, Northwest University, Xi'an 710127, China;
5.
Aliben Science & Technology Co., Ltd, Chengdu 611930, China

Corresponding author: DUAN Yi-Xiang, yduan@scu.edu.cn
Received Date: 23 April 2021
Revised Date: 21 June 2021

Fund Project: Supported by the Special Project of Major Scientific Instruments and Equipment in Sichuan Province, China (No.2019ZDZX0036) and the Key Research and Development Program of Shaanxi Province, China (No.2019ZDLSF01-03).

Ion mobility spectrometry (IMS) is a rapid separation technique that has been successfully used for detection of chemical warfare agents, drugs and explosives. The key component of IMS is the drift tube, which plays an important role in effectively separating substances. Traditionally, the drift tube is a fixed-length separation space in which the influence of a uniformly applied weak electric field. In this work, the performance of traveling wave ion mobility spectrometer (TWIMS) was characterized by traveling wave voltage amplitudes, traveling wave speeds, ion gate pulse widths and working pressures. When the traveling wave field voltage amplitude was 50 V, the traveling wave field moving speed was 162.5 m/s, the ion gate pulse width was 13 ms, and the working pressure was 170 Pa, the device demonstrated highly analytical performance and achieved an ion mobility resolution comparable to a commercial traveling wave ion mobility time-of-flight mass spectrometry (TWIMS-MS). Finally, reserpine was used to test the linear response range of the TWIMS. The results showed that the linear response range of the TWIMS was greater than two orders of magnitude and the limit of detection could reach 2.5 ng/mL. The device was expected to be used in conjunction with a time-of-flight mass spectrometer.
- Traveling wave,
- Ion mobility spectroscopy,
- Time of flight mass spectrometer
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