Citation: HAN Dan-Dan, ZHANG Jin-Feng, DENG Ji-Nan, HU Ning, YANG Jun. Preparation and Sensing Studies of Flow Focusing Microfluidic Chip-based Liquid Crystal Droplet[J]. Chinese Journal of Analytical Chemistry, ;2021, 49(10): 1678-1685. doi: 10.19756/j.issn.0253-3820.210443 shu

Preparation and Sensing Studies of Flow Focusing Microfluidic Chip-based Liquid Crystal Droplet

Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400030, China

Corresponding author: DENG Ji-Nan, YANG Jun,
Received Date: 16 April 2021
Revised Date: 11 August 2021

Fund Project: Supported by the National Natural Science Foundation of China (No.81871450) and the Fundamental Research Funds for the Central Universities, China (No.2020CDJQY-A058).

Liquid crystal (LC) droplets are promising for biosensor applications. However, the nonuniform size of LC droplets has limited their sensing performance. In this work, the generation of monodispersed LC droplets using a flow-focusing microfluidic chip was systematically investigated. With the nematic liquid crystal as the dispersed phase and sodium dodecyl sulfate aqueous/polyvinyl alcohol solution as the continuous phase, different flow patterns for the generation of LC droplet were studied. The effects of flow rates of the two phases, the viscosity of the continuous phase and the width of the orifice on the size of the generated LC droplets were also investigated. Finally, the size effect of the LC droplets on the sensing performance for deoxycholic acid (DCA), a potential biomarker of liver and intestinal diseases, was preliminarily explored. The results showed that the detection limit of LC droplets for DCA decreased from (383 ±23.6) μmol/L to (140 ±14.1) μmol/L when the diameter of LC droplets increased from 38 μm to 77 μm.
- Microfluidics,
- Liquid crystal droplets,
- Flow-focusing,
- Biosensing,
- Two-phase flow
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