Citation: WANG Wei-Min, JIN Liu-Yu, QIAN Bing-Jun, XU Fu-Xing, DING Chuan-Fan. Optimization Procedure of Mass Range for Electron Impact Ion Source Ion Trap Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(2): 198-205. doi: 10.19756/j.issn.0253-3820.210442 shu

Optimization Procedure of Mass Range for Electron Impact Ion Source Ion Trap Mass Spectrometry

Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province, Institute of Mass Spectrometry, School of Materials Science & Chemical Engineering, Ningbo University, Ningbo 315211, China

Corresponding author: XU Fu-Xing, DING Chuan-Fan,
Received Date: 16 April 2021
Revised Date: 21 September 2021

Fund Project: Supported by the National Natural Science Found of China (Nos.21803013, 21927805) and the Dalian Institute of Chemical Physics Fund, Chinese Academy of Sciences (Nos.DICP ZZBS201701, DICP I201951)

Electron impact ion source (EI) is a kind of highly efficient ionization source that can be used in vacuum. The ionization efficiency of EI can reach 0.1%, and EI can ionize almost all substances. In recent years, the development of electron impact ion source-ion trap mass spectrometry (EI-ITMS) has made great progress, which makes portable gas chromatograph-mass spectrometer (GC-MS) widely used in the rapid qualitative and quantitative detection of toxic and harmful substances. However, the performance debugging of EI-ITMS instrument is still very complicated. Firstly, the ion transmission efficiency of EI needs to set up a suitable lens voltage. Secondly, EI ionization will produce a large number of fragmented ions. To ensure the best mass range, it is necessary to continuously fine tune the relevant voltage parameters of the ion trap mass analyzer. In this work, a set of mass range optimization debugging program was established on the basis of homemade EI-ITMS devices. The developed EI-ITMS were connected in the axial direction. The gas sample entered the EI source through a 75-μm quartz capillary tube, and then the generated ions were accelerated and focused under the action of the extraction electrode system and flowed to the ion trap. The frontcap voltage of the ion trap was used as the gate to control the entry of ions. The parameters of the EI were optimized, and the motion trajectory and transmission efficiency of the ions under the experimental conditions were simulated using simion software. The established mass range optimization program was helpful to alleviate the mass discrimination effect of ion trap mass analyzer and realized the analysis of small mass fragments produced by EI ionization. Experiments showed that the established program could successfully optimize the detection of acetone fragment ion m/z 43 and perfluorotributylamine fragment ion m/z 414. This work laid a foundation for the introduction of chromatographic analysis.
- Electron impact ionization,
- Simion software,
- Ion trapping efficiency,
- Ion trap mass cutoff
1. [1]
  SETO Y. On-site Detection of Chemical Warfare Agents. In Handbook of Toxicology of Chemical Warfare Agents, Elsevier, 2020: 983-1003.
2. [2]
  BARFIDOKHT A, MISHRA R K, SEENIVASAN R, LIU S, HUBBLE L J, WANG J, HALL D A. Sens. Actuators, B, 2019, 296: 126422.
3. [3]
  SEDDAOUI N, AMINE A. Talanta, 2021, 230: 122346.
4. [4]
  MANCINI D, PERCOT A, BELLOT-GURLETELLOT L, COLOMBAN P, CARNAZZA P. Talanta, 2021, 227: 122159.
5. [5]
  HILL H H, MARTIN S J. Pure Appl. Chem., 2002, 74(12): 2281-2291.
6. [6]
  MEUZELAAR H, DWORZANSKI J P, ARNOLD N S, MCCLENNEN W H, WAGER D J. Field Anal. Chem. Technol., 2015, 4(1): 3-13.
7. [7]
  CONTRERAS J A, MURRAY J A, TOLLEY S E, OLIPHANTJ L, TOLLEY H D, LAMMERT S A, LEE E D, LATER D W, LEE M L. J. Am. Soc. Mass Spectrom., 2008, 19(10): 1425-1434.
8. [8]
  TRUONG T V, SADOWSKI C S, PORTER N L, RANDS A D, RICHTER B E, BRANDE T, LATER D W,LEE M L. Scient Chromatogr., 2014, 6(1): 13-26.
9. [9]
  SMITH P A, LEPAGE C J, LUKACS M, MARTIN N, SHUFUTINSKY A, SAVAGE P B. Int. J. Mass Spectrom., 2010, 295(3): 1387-3806.
10. [10]
  GUO Q, GAO L, ZHAI Y, XU W. Chin. Chem. Lett., 2018, 29: 1578-1584.
11. [11]
  BOUCHONNET S. Introduction to GC-MS Coupling. CRC Press: New York, 2013.
12. [12]
  JONSCHER K R, YATES J R. Anal. Biochem., 1997, 244(1): 1-15.
13. [13]
  XU F, XU C, DING L, ZHOU M, DING C F. Int. J. Mass Spectrom., 2018, 428: 29-34.
14. [14]
  DING L, SUDAKOV M, KUMASHIRO S. Int. J. Mass Spectrom., 2002, 221(2): 117-138.
15. [15]
  WANG Y, SCHUBERT M, INGENDOH A, FRANZEN J. Rapid Commun. Mass Spectrom., 2000, 14(1): 12-17.
16. [16]
  SPLENDORE M, LAUSEVIC M, LAUSEVIC Z, MARCH R. Rapid Commun. Mass Spectrom.,1997, 11(2): 228-233.
17. [17]
  BLAIN M G, RITER L S, CRUZ D, AUSTIN D E, WU G, PLASS W R, COOKS R G. Int. J. Mass Spectrom., 2004, 236(1-3): 91-104.
1. [1]
  Wang Shuang , Fu Xiaoqi , Yao Shanshan . Synergistic optimization of ion migration and electron transfer in sodium-ion battery cathode materials. Acta Physico-Chimica Sinica, 2026, 42(5): 100206-. doi: 10.1016/j.actphy.2025.100206
2. [2]
  Ruiyun Liu , Ping Wang , Xuefei Wang , Feng Chen , Huogen Yu . Work-function-engineered Mo 4d electronic structure modulation in Mo₂C MXene cocatalyst for efficient photocatalytic H₂ evolution. Acta Physico-Chimica Sinica, 2025, 41(11): 100137-0. doi: 10.1016/j.actphy.2025.100137
3. [3]
  Zhiming Feng , Lili Wu , Chengming Wang . Doubly Oxidized Carbene. University Chemistry, 2025, 40(9): 326-331. doi: 10.12461/PKU.DXHX202411008
4. [4]
  Yuyao Wang , Zhitao Cao , Zeyu Du , Xinxin Cao , Shuquan Liang . Research Progress of Iron-based Polyanionic Cathode Materials for Sodium-Ion Batteries. Acta Physico-Chimica Sinica, 2025, 41(4): 100035-0. doi: 10.3866/PKU.WHXB202406014
5. [5]
  Pingwei Wu . Application of Diamond Software in Simplex Teaching. University Chemistry, 2024, 39(3): 118-121. doi: 10.3866/PKU.DXHX202311043
6. [6]
  Wenjun Zheng . Application in Inorganic Synthesis of Ionic Liquids. University Chemistry, 2024, 39(8): 163-168. doi: 10.3866/PKU.DXHX202401020
7. [7]
  Guoze Yan , Bin Zuo , Shaoqing Liu , Tao Wang , Ruoyu Wang , Jinyang Bao , Zhongzhou Zhao , Feifei Chu , Zhengtong Li , Yamauchi Yusuke , Melhi Saad , Xingtao Xu . Opportunities and Challenges of Capacitive Deionization for Uranium Extraction from Seawater. Acta Physico-Chimica Sinica, 2025, 41(4): 100032-0. doi: 10.3866/PKU.WHXB202404006
8. [8]
  Jing Tan , Bo Zheng , Lingyan Gao . Application of Crown Ether-Based Artificial Ion Transporters. University Chemistry, 2026, 41(2): 232-237. doi: 10.12461/PKU.DXHX202501010
9. [9]
  Zilin Hu , Yaoshen Niu , Xiaohui Rong , Yongsheng Hu . Suppression of Voltage Decay through Ni³⁺ Barrier in Anionic-Redox Active Cathode for Na-Ion Batteries. Acta Physico-Chimica Sinica, 2024, 40(6): 2306005-0. doi: 10.3866/PKU.WHXB202306005
10. [10]
  Wenyan Dan , Weijie Li , Xiaogang Wang . The Technical Analysis of Visual Software ShelXle for Refinement of Small Molecular Crystal Structure. University Chemistry, 2024, 39(3): 63-69. doi: 10.3866/PKU.DXHX202302060
11. [11]
  Zehua Zhao , Xiaoyan An , Jinrong Xu , Ling Yang , Hao Zhao , Zhongyun Wu . Independent Development and Application of Calorimetric Experiment Data Acquisition and Processing Software. University Chemistry, 2025, 40(11): 402-408. doi: 10.12461/PKU.DXHX202505045
12. [12]
  Ruijuan Qu , Wenqian Cao , Shengnan Zhang , Xiaoyu Li , Yumeng Qi , Junyan Wei , Zunyao Wang . Exploration and Practice of Reforming the “Modeling Methods in Environmental Science” Course through Integration of Information Technology Software. University Chemistry, 2026, 41(4): 140-148. doi: 10.12461/PKU.DXHX202503030
13. [13]
  Hong LI , Xiaoying DING , Cihang LIU , Jinghan ZHANG , Yanying RAO . Detection of iron and copper ions based on gold nanorod etching colorimetry. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 953-962. doi: 10.11862/CJIC.20230370
14. [14]
  Feiya Cao , Qixin Wang , Pu Li , Zhirong Xing , Ziyu Song , Heng Zhang , Zhibin Zhou , Wenfang Feng . Magnesium-Ion Conducting Electrolyte Based on Grignard Reaction: Synthesis and Properties. University Chemistry, 2024, 39(3): 359-368. doi: 10.3866/PKU.DXHX202308094
15. [15]
  Xuyang Wang , Jiapei Zhang , Lirui Zhao , Xiaowen Xu , Guizheng Zou , Bin Zhang . Theoretical Study on the Structure and Stability of Copper-Ammonia Coordination Ions. University Chemistry, 2024, 39(3): 384-389. doi: 10.3866/PKU.DXHX202309065
16. [16]
  Dongqi Cai , Fuping Tian , Zerui Zhao , Yanjuan Zhang , Yue Dai , Feifei Huang , Yu Wang . Exploration of Factors Influencing the Determination of Ion Migration Number by Hittorf Method. University Chemistry, 2024, 39(4): 94-99. doi: 10.3866/PKU.DXHX202310031
17. [17]
  Jiayu Tang , Jichuan Pang , Shaohua Xiao , Xinhua Xu , Meifen Wu . Improvement for Measuring Transference Numbers of Ions by Moving-Boundary Method. University Chemistry, 2024, 39(5): 193-200. doi: 10.3866/PKU.DXHX202311021
18. [18]
  Yifeng Xu , Jiquan Liu , Bin Cui , Yan Li , Gang Xie , Ying Yang . “Xiao Li’s School Adventures: The Working Principles and Safety Risks of Lithium-ion Batteries”. University Chemistry, 2024, 39(9): 259-265. doi: 10.12461/PKU.DXHX202404009
19. [19]
  Zeqiu Chen , Limiao Cai , Jie Guan , Zhanyang Li , Hao Wang , Yaoguang Guo , Xingtao Xu , Likun Pan . Advanced electrode materials in capacitive deionization for efficient lithium extraction. Acta Physico-Chimica Sinica, 2025, 41(8): 100089-0. doi: 10.1016/j.actphy.2025.100089
20. [20]
  Xintong Zhu , Bin Cao , Chong Yan , Cheng Tang , Aibing Chen , Qiang Zhang . Advances in coating strategies for graphite anodes in lithium-ion batteries. Acta Physico-Chimica Sinica, 2025, 41(9): 100096-0. doi: 10.1016/j.actphy.2025.100096

Get Citation

PDF

XML

Metrics

PDF Downloads(10)
Abstract views(1665)
HTML views(332)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142