Citation: WANG Wei-Min, JIN Liu-Yu, QIAN Bing-Jun, XU Fu-Xing, DING Chuan-Fan. Optimization Procedure of Mass Range for Electron Impact Ion Source Ion Trap Mass Spectrometry[J]. Chinese Journal of Analytical Chemistry, ;2022, 50(2): 198-205. doi: 10.19756/j.issn.0253-3820.210442 shu

Optimization Procedure of Mass Range for Electron Impact Ion Source Ion Trap Mass Spectrometry

Key Laboratory of Advanced Mass Spectrometry and Molecular Analysis of Zhejiang Province, Institute of Mass Spectrometry, School of Materials Science & Chemical Engineering, Ningbo University, Ningbo 315211, China

Corresponding author: XU Fu-Xing, DING Chuan-Fan,
Received Date: 16 April 2021
Revised Date: 21 September 2021

Fund Project: Supported by the National Natural Science Found of China (Nos.21803013, 21927805) and the Dalian Institute of Chemical Physics Fund, Chinese Academy of Sciences (Nos.DICP ZZBS201701, DICP I201951)

Electron impact ion source (EI) is a kind of highly efficient ionization source that can be used in vacuum. The ionization efficiency of EI can reach 0.1%, and EI can ionize almost all substances. In recent years, the development of electron impact ion source-ion trap mass spectrometry (EI-ITMS) has made great progress, which makes portable gas chromatograph-mass spectrometer (GC-MS) widely used in the rapid qualitative and quantitative detection of toxic and harmful substances. However, the performance debugging of EI-ITMS instrument is still very complicated. Firstly, the ion transmission efficiency of EI needs to set up a suitable lens voltage. Secondly, EI ionization will produce a large number of fragmented ions. To ensure the best mass range, it is necessary to continuously fine tune the relevant voltage parameters of the ion trap mass analyzer. In this work, a set of mass range optimization debugging program was established on the basis of homemade EI-ITMS devices. The developed EI-ITMS were connected in the axial direction. The gas sample entered the EI source through a 75-μm quartz capillary tube, and then the generated ions were accelerated and focused under the action of the extraction electrode system and flowed to the ion trap. The frontcap voltage of the ion trap was used as the gate to control the entry of ions. The parameters of the EI were optimized, and the motion trajectory and transmission efficiency of the ions under the experimental conditions were simulated using simion software. The established mass range optimization program was helpful to alleviate the mass discrimination effect of ion trap mass analyzer and realized the analysis of small mass fragments produced by EI ionization. Experiments showed that the established program could successfully optimize the detection of acetone fragment ion m/z 43 and perfluorotributylamine fragment ion m/z 414. This work laid a foundation for the introduction of chromatographic analysis.
- Electron impact ionization,
- Simion software,
- Ion trapping efficiency,
- Ion trap mass cutoff
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